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The MRN-CtIP pathway is required for metaphase chromosome alignment.

Rozier(Lorene),Guo(Yige),Peterson(Shaun),Sat… Mol Cell 2013-05-23

...Rad50, and Nbs1) complex and CtIP are required for accurate chromosome segregation. Depletion of Mre11 or CtIP, antibody...

The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus…

Gautam(Dipendra),Bridge(Eileen) J Virol 2013-09-18

...Rad50/Nbs1 (MRN) sensor complex, which is a critical component for the ability of cells to respond to DNA damage. E4 mut...

Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven …

Lee(Ji-Hoon),Mand(Michael R),Deshpande(Rajas… J Biol Chem 2013-07-12

...Rad50 protein. Here we use an ATP analog-sensitive form of ATM to determine that ATP binding, but not hydrolysis, by Rad...

Tel1 and Rad51 are involved in the maintenance of telomeres with capping defici…

Di Domenico(Enea Gino),Mattarocci(Stefano),C… Nucleic Acids Res 2013-09-20

...Rad50. Generation of telomeric G-tail, which is cell cycle regulated, depends on the MRX (Mre11-Rad50-Xrs2) complex in t...

Organization and Evolution of Drosophila Terminin: Similarities and Differences…

Raffa(Grazia D),Cenci(Giovanni),Ciapponi(Lau… Front Oncol 2013-05-16

...Rad50-Nbs (MRN) complex, and the Woc transcription factor. These proteins do not share the terminin properties; they are...

Replication and fine mapping of asthma-associated loci in individuals of Africa…

Kantor(David B),Palmer(Cameron D),Young(Tayl… Hum Genet 2013-10-30

...RAD50/IL13, implicated in studies of European ancestry individuals, replicates in individuals largely of African ancestr...

The neural crest transcription factor Brn3a is expressed in melanoma and requir…

Hohenauer(Tobias),Berking(Carola),Schmidt(An… EMBO Mol Med 2013-11-05

...Rad50-containing nuclear foci. Activated DNA damage signalling caused stabilization of the tumour suppressor p53, which ...

Multiple genetic pathways regulate replicative senescence in telomerase-deficie…

Ballew(Bari J),Lundblad(Victoria) Aging Cell 2013-12-16

...Rad50-Xrs2) complex, as well as negative (Rif2) and positive (Tel1) regulators of this complex, comprise a single pathwa...

Impaired resection of meiotic double-strand breaks channels repair to nonhomolo…

Yin(Yizhi),Smolikove(Sarit) Mol Cell Biol 2013-08-23

...Rad50, and Xrs2/Nbs1) complex required for meiotic DSB formation and for resection in Saccharomyces cerevisiae. In Caeno...

SMC1-mediated intra-S-phase arrest facilitates bocavirus DNA replication.

Luo(Yong),Deng(Xuefeng),Cheng(Fang),Li(Yi),Q… J Virol 2013-05-02

...Rad50-Nbs1 (MRN) complex. In conclusion, the feedback loop between MVC DNA replication and the intra-S-phase arrest is m...

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