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NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA d…

Wen(J),Cerosaletti(K),Schultz(K J),Wright(J … Oncogene 2013-11-08

...RAD50/NBN complex re-distributes to the sites of DNA double-strand breaks (DSBs) where each of its individual components...

Immunohistochemical analysis of medullary breast carcinoma autoantigens in diff…

Kostianets(Olga),Antoniuk(Stepan),Filonenko(… Diagn Pathol 2013-05-10

...RAD50, FAM50A, RBPJ, PABPC4, LRRFIP1 with cancer restricted serological profile in different histological types of breas...

The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair.

Reis(Clara Correia),Batista(Sílvia),Ferreira… EMBO J 2013-02-06

...Rad50-Nbs1) complex prevents NHEJ at telomeres and, as a result, rescues taz1Δ lethality in G1. Neither Tel1(ATM) activa...

DNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archa…

Delmas(Stéphane),Duggin(Iain G),Allers(Thors… Mol Microbiol 2013-07-02

...Rad50 complex, suggesting a link to DNA double-strand break repair. However, compaction was observed in a radA mutant, i...

The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.

Thompson(Ruth),Montano(Ryan),Eastman(Alan) PLoS One 2013-02-12

...Rad50/Nbs1 complex is known to be responsible for the resection of DSB to ssDNA. However, we show that inhibition of the...

Identification of a novel NBN truncating mutation in a family with hereditary p…

Zuhlke(Kimberly A),Johnson(Anna M),Okoth(Lin… Fam Cancer 2013-04-23

...RAD50/NBN genomic stability complex. The S706X mutation truncates the protein in a highly conserved region of NBN near t...

Evaluation of candidate biomarkers to predict cancer cell sensitivity or resist…

Oplustilova(Lenka),Wolanin(Kamila),Mistrik(M… Cell Cycle 2013-03-01

...Rad50-Nbs1 (MRN) complex sensitized cancer cells to PARP-1i, while p53 status was less predictive, even in response to P...

MAIGO2 is involved in abscisic acid-mediated response to abiotic stresses and G…

Zhao(Pengshan),Liu(Fei),Zhang(Bo),Liu(Xin),W… Physiol Plant 2013-12-09

...Rad50-interacting protein, is found to be required for the responses to salt stress, osmotic stress and abscisic acid in...

Innate immunity and non-Hodgkin's lymphoma (NHL) related genes in a nested case…

Park(Sue K),Yang(Jae Jeong),Oh(Sohee),Cho(Li… PLoS One 2013-02-28

...RAD50, CASP7, CHUK, CD79B, and CLDN9) with a permutated p-value <0.01 were re-genotyped in the Replication phase among 3...

Current concepts of IgE regulation and impact of genetic determinants.

Potaczek(D P),Kabesch(M) Clin Exp Allergy 2013-01-08

...RAD50, IL13, IL4), 12q13 (STAT6), 6p21.3 (HLA-DRB1) and 16p12 (IL4R, IL21R). In this review, we analyse the potential ro...

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