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CtIP protein dimerization is critical for its recruitment to chromosomal DNA do…

Wang(Hailong),Shao(Zhengping),Shi(Linda Z),H… J Biol Chem 2012-08-24

...Rad50-Nbs1 (MRN) complex and plays an essential role in homologous recombination (HR)-mediated DNA double-stranded break...

Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and …

Someya(Masanori),Sakata(Koh-ichi),Matsumoto(… J Radiat Res 2012-08-24

...Rad50/NBS1 complex-dependent resection of DNA double-strand break ends. The phosphorylation of RPA by irradiation was pa...

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homol…

Falck(Jacob),Forment(Josep V),Coates(Julia),… EMBO Rep 2012-09-28

...RAD50–NBS1 (MRN) complex is an important sensor of DNA double-strand breaks (DSBs) and facilitates DNA repair by homolog...

Mre11-dependent degradation of stalled DNA replication forks is prevented by BR…

Ying(Songmin),Hamdy(Freddie C),Helleday(Thom… Cancer Res 2012-08-10

...Rad50-Nbs1) complex that plays a role in the restart of stalled replication forks and enhanced resection at stalled repl...

Skp2 E3 ligase integrates ATM activation and homologous recombination repair by…

Wu(Juan),Zhang(Xian),Zhang(Ling),Wu(Ching-Yu… Mol Cell 2012-07-23

...Rad50/NBS1 (MRN) complex is thought to be a critical sensor that detects damaged DNA and recruits ATM to DNA foci for ac...

Rare germline large rearrangements in the BRCA1/2 genes and eight candidate gen…

Rouleau(E),Jesson(B),Briaux(A),Nogues(C),Cha… Breast Cancer Res Treat 2012-11-06

...RAD50, RAD51, BRIP1, RAP80 and PALB2. A dedicated zoom-in CGH-array was applied to screen for rearrangements in 472 unre...

DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation an…

Krenzlin(Harald),Demuth(Ilja),Salewsky(Basti… PLoS Genet 2012-09-04

...RAD50/NBN (MRN) complex essential for processing DNA double-strand breaks. Cardinal features of NBS are immunodeficiency...

Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts.

Kumar(Sanjay),Yoo(Hae Yong),Kumagai(Akiko),S… Cell Cycle 2012-09-13

...Rad50-Nbs1 (MRN) complex, which are key regulators of checkpoint responses to double-stranded DNA breaks (DSBs). Depleti...

A structural basis for the assembly and functions of a viral polymer that inact…

Ou(Horng D),Kwiatkowski(Witek),Deerinck(Thom… Cell 2012-12-28

...RAD50/NBS1 (MRN) tumor suppressors. We identify oligomerization mutants and solve the crystal structure of E4-ORF3. E4-O...

Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA d…

Wohlbold(Lara),Merrick(Karl A),De(Saurav),Am… PLoS Genet 2012-11-05

...Rad50-Nbs1 complex required for normal DNA damage repair and checkpoint signaling-dependent on a consensus CDK recogniti...

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