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The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resect…

Costelloe(Thomas),Louge(Raphaël),Tomimatsu(N… Nature 2012-11-12

...Rad50-Xrs2 complex (Xrs2 is known as NBN or NBS1 in humans) and Sae2 (known as RBBP8 or CTIP in humans) initiate end res...

Demonstration of phosphoryl group transfer indicates that the ATP-binding casse…

Randak(Christoph O),Ver Heul(Amanda R),Welsh… J Biol Chem 2012-12-28

...Rad50 and a structural maintenance of chromosome (SMC) protein, challenge the model that the function of all ABC protein...

Recognition, signaling, and repair of DNA double-strand breaks produced by ioni…

Thompson(Larry H) Mutat Res 2012-11-06

...RAD50-NBS1 complex. Thus, the nature of the intricate coordination of repair processes with cell cycle progression is be...

Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paral…

Sohn(Sook-Young),Hearing(Patrick) J Virol 2012-11-21

...Rad50-Nbs1 (MRN) complex plays a key role in the DNA damage response, presenting challenges for DNA viruses and retrovir...

The wobble nucleotide-excising anticodon nuclease RloC is governed by the zinc-…

Klaiman(Daniel),Steinfels-Kohn(Emmanuelle),K… Nucleic Acids Res 2012-12-18

...Rad50. Previous work revealed that ZH mutations activate RloC's ACNase. Data shown here suggest that RloC has an interna...

Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.

Khalil(Hilal S),Tummala(Hemanth),Hupp(Tedd R… Exp Biol Med (Maywood) 2012-10-23

...Rad50-Nbs1 (MRN) DNA repair complex, and orchestrates signalling cascades that initiate the DNA damage response. Cells l...

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like…

Schiller(Christian B),Lammens(Katja),Guerini… Nat Struct Mol Biol 2012-09-13

The Mre11-Rad50-Nbs1 (MRN) complex tethers, processes and signals DNA double-strand breaks, promoting genomic stability....

Role and clinical significance of lymphocyte mitochondrial dysfunction in type …

Khan(Saba),Raghuram(Gorantla V),Bhargava(Arp… Transl Res 2012-01-05

...Rad50, and Nbs1). A higher frequency (>2%) of stable chromosomal anomalies with loss of telomere integrity was observed ...

Crystal structure of the NurA-dAMP-Mn2+ complex.

Chae(Jina),Kim(Young Chang),Cho(Yunje) Nucleic Acids Res 2012-05-08

...Rad50 and HerA. We have determined the crystal structures of apo- and dAMP-Mn(2)(+)-bound NurA from Pyrococcus furiousus...

Differential function of NBS1 and ATR in neurogenesis.

Zhou(Zhongwei),Bruhn(Christopher),Wang(Zhao-… DNA Repair (Amst) 2012-05-18

...RAD50/NBS) helps to activate ATM in response to DNA double strand breaks (DSBs) and also facilitates ATR activation by c...

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