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Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized …

Wu(S),Zheng(L),Hei(Z),Zhou(JB),Li(G),Li(P),W… Cell Mol Life Sci 2022-02-08

...AIMP2), human LysRS is free from the MSC. The interaction with AIMP2 stabilizes the closed conformation of LysRS, thereb...

The RNA editing enzyme ADAR modulated by the rs1127317 genetic variant diminish…

Hua(H),Zeng(J),Xing(H),He(Y),Han(L),Zhang(N)… Life Sci 2022-05-01

...AIMP2) in prognosis of NSCLC patients receiving EGFR-TKIs. We identified the ADAR rs1127309, rs1127317, and rs2229857 SN...

The Identification of Prognostic and Metastatic Alternative Splicing in Skin Cu…

Huang(R),Li(M),Zeng(Z),Zhang(J),Song(D),Hu(P… Cancer Control 2022-00-00

...AIMP2) regulated by CDC-like kinase 1 (CLK1) was associated with the metastasis and stage of SKCM. Besides, the overlapp...

Identification and evaluation of midbrain specific longevity-related genes in e…

Kim(H),Huh(YJ),Kim(JH),Jo(M),Shin(JH),Park(S… Front Aging Neurosci 2022-00-00

...aimp2, hexb, cacybp, akt2, nrf1, axin1, wwp2, sp2, dnajb9, notch, traf7, and lrp1. A detailed biochemical analysis of th...

The Absence of Parkin Does Not Promote Dopamine or Mitochondrial Dysfunction in…

Scott(L),Karuppagounder(SS),Neifert(S),Kang(… J Neurosci 2022-00-07

...AIMP2 remained unchanged, suggesting no parkin dysfunction. In summary, we were unable to observe dopaminergic neurodege...

Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregat…

Shin(JY),Lee(B),Ham(S),Kim(JH),Kim(H),Kim(H)… Biomed Pharmacother 2022-12-00

...AIMP2 aggregation bind to AIMP2, disaggregate the pre-formed AIMP2 aggregates, and prevented AIMP2/α-synuclein coaggrega...

Discovery of benzodioxane analogues as lead candidates of AIMP2-DX2 inhibitors.

Lee(B),Gyu Kim(D),Mi Kim(Y),Kim(S),Choi(I) Bioorg Med Chem Lett 2022-00-01

...AIMP2) plays a vital role in protein synthesis. However, a splicing variant in which the second of the four exons of AIM...

Deciphering the molecular landscape of microcephaly in 87 Indian families by ex…

Masih(S),Moirangthem(A),Shambhavi(A),Rai(A),… Eur J Med Genet 2022-06-00

...AIMP2, ANKLE2, NCAPD2 and TRIT1.

Knockdown of Golgi Stress-Responsive Caspase-2 Ameliorates HLD17-Associated AIM…

Ochiai(A),Sawaguchi(S),Memezawa(S),Seki(Y),M… Neurochem Res 2022-09-00

...AIMP2 localizes AIMP2 proteins as aggregates into the Golgi bodies in mouse oligodendroglial FBD-102b cells. Wild type A...

Comparative proteomic profiling reveals a pathogenic role for the O-GlcNAcylate…

Li(R),Li(Y),Tian(M),Zhang(H),Lou(L),Liu(K),Z… FEBS Lett 2022-01-00

...AIMP2 and PARP1 levels in vitro. Mechanistically, O-GlcNAcylation increased AIMP2 protein stability, leading to its aggr...

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