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Targeting HIF-2α in colorectal cancer reveals a cholesterol biosynthesis-depe...

Dalal(PJ),Singhal(R),Hu(B),Stark(D),Rossit... Cancer Metab 2026-02-12

...CRISPR metabolic screen. This revealed cholesterol biosynthesis as a critical dependency. Targeting this pathway with cl...

Ptch2 Deficiency Triggers Lipoma Formation and Adipogenic Transcriptome Repro...

Zhao(C),Liu(X),Peng(X),Chen(Y),Peng(S),Liu... Animals (Basel) 2026-01-28

...CRISPR/Cas9-mediated ptch2 homozygous mutation model in Nile tilapia (Oreochromis niloticus), we found that Ptch2 defici...

Advancements, Challenges, and Future Perspectives of Soybean-Integrated Pest ...

de F Bueno(A),Hoback(WW),Colmenarez(YC),Va... Plants (Basel) 2026-01-24

...CRISPR-based control strategies, among other sustainable alternatives intensively researched around the world.

Advancing Bongkrekic Acid Detection: From Conventional Instrumental Analysis ...

Chen(Z),He(D),Yu(W),Fu(X),Zhang(L),Zhang(M... Foods 2026-01-30

...CRISPR-Cas-mediated signal amplification, and multimodal integrated platforms. To translate this potential into practica...

Naked-Eye and On-Site Detection of Staphylococcus aureus via DNAzyme-Assisted...

Liu(X),Gao(R),Wang(R),Xiong(Z),Wang(G),Ai(... Foods 2026-02-05

...CRISPR/Cas12a technology and DNAzyme colorimetric signal output to design a naked-eye output instant detection platform ...

Pmel17 Deficiency Affects Melanogenesis and Promotes Tumor Vascularization.

Sopel(J),Sarad(K),Kozinska(A),Mokrzyński(K... Int J Mol Sci 2026-01-23

...CRISPR/Cas9-mediated genome editing. A viability assay revealed no significant differences between wild-type (WT) and Pm...

Neurofibromin 1 (NF1) Splicing Mutation c.61-2A>G: From Aberrant mRNA Process...

Blazyte(A),Lee(H),Yoon(C),Jeon(S),Lee(J),B... Int J Mol Sci 2026-01-23

...CRISPR-Cas9 prime editing is the only viable approach for in vivo correction. This study provides the first comprehensiv...

Molecular Regulators of In Vitro Regeneration in Wheat: Roles of Morphogenic ...

Kowalik(S),Samoń(M),Przyborowski(M) Int J Mol Sci 2026-01-27

...CRISPR-Cas-edited plants, and facilitate genotype-independent transformation. We also discuss epigenetic and metabolic c...

Tyrosinase-Deficient Skin Melanophore Lineage in Xenopus tropicalis Tadpoles ...

Jiang(Y),Chen(Y),Huang(Z),Chen(L),Huang(X) Int J Mol Sci 2026-01-29

...CRISPR-Cas9 significantly reduced the fluorescence intensity induced by tyrosinase deficiency, indicating an essential r...

A Translational Roadmap for Neurological Nonsense Mutation Disorders.

Li(J),Zhu(Z),Xu(S) Int J Mol Sci 2026-01-30

...CRISPR-based platforms. Yet clinical translation remains hampered by inefficient CNS delivery, variable efficacy, and th...

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