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Intensity modulated radiotherapy induces pro-inflammatory and pro-survival resp…

El-Saghire(Houssein),Vandevoorde(Charlot),Os… Int J Oncol 2014-11-26

...RAD17, SMC6 and MRE11A) were confirmed by quantitative RT-PCR. This study emphasizes that the risk assessment of health ...

Rapid induction of alternative lengthening of telomeres by depletion of the his…

O'Sullivan(Roderick J),Arnoult(Nausica),Lack… Nat Struct Mol Biol 2014-04-15

...RAD17 and BLM and negatively regulated by EXO1 and DNA2. The induction of ALT phenotypes as a consequence of ASF1 deplet...

The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interacti…

Burgess(Rebecca J),Han(Junhong),Zhang(Zhiguo) J Biol Chem 2014-06-20

...rad17Δ cells exhibit defects in the deposition of newly synthesized H3-H4 onto replicated DNA. Finally, deletion of RAD1...

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response t…

Wang(Qinhong),Goldstein(Michael),Alexander(P… EMBO J 2014-06-03

...Rad17 is phosphorylated by ATM at a novel Thr622 site resulting in a direct interaction of Rad17 with NBS1, facilitating...

Direct and indirect control of the initiation of meiotic recombination by DNA d…

Argunhan(Bilge),Farmer(Sarah),Leung(Wing-Kit… PLoS One 2014-02-11

...Rad17 (a critical component of the ATR pathway) lead to an increase in DSB formation (chromosomes VII and II were tested...

Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine.

Fredebohm(Johannes),Wolf(Jonas),Hoheisel(Jör… J Cell Sci 2014-05-22

...RAD17 potentiated gemcitabine cytotoxicity in the pancreatic cancer cell lines BxPC-3 and MiaPaca-2 and in the primary c...

c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telome…

Islam(Md Ashraful),Thomas(Shelia D),Murty(Vu… J Biol Chem 2014-05-27

...RAD17 and RAD50), double-stranded break repair molecule 53BP1, G2 checkpoint regulators (CHK1 and CHK2), and anti-apopto...

Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 …

Shanmugam(Ilanchezhian),Abbas(Mohammad),Ayou… J Biol Chem 2014-12-16

Rad17 is a subunit of the Rad9-Hus1-Rad1 clamp loader complex, which is required for Chk1 activation after DNA damage. R...

v-Src inhibits the interaction between Rad17 and Rad9 and induces replication f…

Fukumoto(Yasunori),Miura(Takahito),Morii(Mar… Biochem Biophys Res Commun 2014-09-21

...Rad17 and Rad9 in chromatin fraction. By contrast, v-Src does not inhibit RPA32 phosphorylation, ATR autophosphorylation...

Phosphoinositide 3-kinase beta controls replication factor C assembly and funct…

Redondo-Muñoz(Javier),Rodríguez(María Josefa… Nucleic Acids Res 2013-04-04

...RAD17. Phosphoinositide 3-kinases (PI3K) are lipid kinases that generate 3-poly-phosphorylated-phosphoinositides at the ...

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