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The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resect…

Costelloe(Thomas),Louge(Raphaël),Tomimatsu(N… Nature 2012-11-12

...Rad50-Xrs2 complex (Xrs2 is known as NBN or NBS1 in humans) and Sae2 (known as RBBP8 or CTIP in humans) initiate end res...

Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA d…

Wohlbold(Lara),Merrick(Karl A),De(Saurav),Am… PLoS Genet 2012-11-05

...Rad50-Nbs1 complex required for normal DNA damage repair and checkpoint signaling-dependent on a consensus CDK recogniti...

Demonstration of phosphoryl group transfer indicates that the ATP-binding casse…

Randak(Christoph O),Ver Heul(Amanda R),Welsh… J Biol Chem 2012-12-28

...Rad50 and a structural maintenance of chromosome (SMC) protein, challenge the model that the function of all ABC protein...

The wobble nucleotide-excising anticodon nuclease RloC is governed by the zinc-…

Klaiman(Daniel),Steinfels-Kohn(Emmanuelle),K… Nucleic Acids Res 2012-12-18

...Rad50. Previous work revealed that ZH mutations activate RloC's ACNase. Data shown here suggest that RloC has an interna...

Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paral…

Sohn(Sook-Young),Hearing(Patrick) J Virol 2012-11-21

...Rad50-Nbs1 (MRN) complex plays a key role in the DNA damage response, presenting challenges for DNA viruses and retrovir...

Recognition, signaling, and repair of DNA double-strand breaks produced by ioni…

Thompson(Larry H) Mutat Res 2012-11-06

...RAD50-NBS1 complex. Thus, the nature of the intricate coordination of repair processes with cell cycle progression is be...

A structural basis for the assembly and functions of a viral polymer that inact…

Ou(Horng D),Kwiatkowski(Witek),Deerinck(Thom… Cell 2012-12-28

...RAD50/NBS1 (MRN) tumor suppressors. We identify oligomerization mutants and solve the crystal structure of E4-ORF3. E4-O...

Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon ca…

Gnosa(Sebastian),Shen(Yang-Mei),Wang(Chao-Ji… J Transl Med 2012-10-31

...Rad50 and apoptosis (p < 0.05).,AEG-1 is up-regulated, at the mRNA and the protein level, during CRC development and agg...

Maintenance of very long telomeres by recombination in the Kluyveromyces lactis…

Xu(Jianing),McEachern(Michael J) Mol Cell Biol 2012-10-08

...Rad50 and Rad51, known to be required for different RTE pathways in Saccharomyces cerevisiae, were not essential for the...

Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppr…

Foster(Steven S),De(Saurav),Johnson(Linda K)… Proc Natl Acad Sci U S A 2012-09-10

...Rad50, and Nbs1) and ATM in apoptosis and suppresses tumorigenesis resulting from hypomorphic alleles of Mre11 or Nbs1. ...

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