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Mimivirus reveals Mre11/Rad50 fusion proteins with a sporadic distribution in e…

Yoshida(Takashi),Claverie(Jean-Michel),Ogata… Virol J 2012-01-12

...Rad50-like domain. A systematic database search revealed twelve additional cases of Mre11/Rad50 (or SbcD/SbcC) fusions i...

Mre11-Rad50 complex crystals suggest molecular calisthenics.

Wyman(Claire),Lebbink(Joyce),Kanaar(Roland) DNA Repair (Amst) 2012-01-30

...Rad50 complexes show the arrangement of these proteins and imply dramatic ligand-induced rearrangements with important f...

Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is requ…

Langerak(Petra),Mejia-Ramirez(Eva),Limbo(Oli… PLoS Genet 2012-01-23

The multifunctional Mre11-Rad50-Nbs1 (MRN) protein complex recruits ATM/Tel1 checkpoint kinase and CtIP/Ctp1 homologous ...

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head compl…

Möckel(Carolin),Lammens(Katja),Schele(Alexan… Nucleic Acids Res 2012-03-14

...Rad50 (MR) complex is an evolutionarily conserved complex of two Rad50 ATPases and a dimer of the Mre11 nuclease that se...

RAD50 and NBS1 are not likely to be susceptibility genes in Chinese non-BRCA1/2…

He(Min),Di(Gen-Hong),Cao(A-Yong),Hu(Zhen),Ji… Breast Cancer Res Treat 2012-08-20

...RAD50 and NBS1, which can be predisposed to breast cancer. The aim of this study is to elucidate the contribution of RAD...

The MRE11 GAR motif regulates DNA double-strand break processing and ATR activa…

Yu(Zhenbao),Vogel(Gillian),Coulombe(Yan),Dub… Cell Res 2012-05-24

...RAD50/NBS1 complex is the primary sensor rapidly recruited to DNA double-strand breaks (DSBs). MRE11 is known to be argi...

Radiation dose effect of DNA repair-related gene expression in mouse white bloo…

Li(Ming-juan),Wang(Wei-wei),Chen(Shi-wei),Sh… Med Sci Monit 2012-01-31

...RAD50 (RAD50 homolog), PLK3 (polo-like kinase 3), GADD45A (growth arrest and DNA damage-inducible, alpha), DDB2 (damage-...

Chromosome integrity at a double-strand break requires exonuclease 1 and MRX.

Nakai(Wataru),Westmoreland(Jim),Yeh(Elaine),… DNA Repair (Amst) 2012-01-03

...RAD50/MRE11/XRS2 (MRX) complex. Using a system for differential fluorescent marking of both sides of an endonuclease-ind...

Analysis of MRE11's function in the 5'-->3' processing of DNA double-strand bre…

Liao(Shuren),Guay(Catherine),Toczylowski(Tho… Nucleic Acids Res 2012-07-30

...RAD50-NBS1 complex, but its contribution to and mechanistic role in resection are not well understood. In this study, we...

A balance between Tel1 and Rif2 activities regulates nucleolytic processing and…

Martina(Marina),Clerici(Michela),Baldo(Veron… Mol Cell Biol 2012-06-25

...Rad50-Xrs2) complex, which is also necessary to maintain telomere length by recruiting the Tel1 kinase. MRX physically i...

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