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Mre11 regulates CtIP-dependent double-strand break repair by interaction with C…

Buis(Jeffrey),Stoneham(Trina),Spehalski(Eliz… Nat Struct Mol Biol 2012-03-21

...Rad50-NBS1 (MRN) complex. Here we show that, in human and mouse, Mre11 controls these events through a direct interactio...

Modularity-based credible prediction of disease genes and detection of disease …

Yao(Xin),Hao(Han),Li(Yanda),Li(Shao) BMC Syst Biol 2011-10-03

...RAD50/NBN.,The phenotype-gene heterogeneous network contains abundant information for not only disease genes discovery b...

Identification of Mre11 as a target for heat radiosensitization.

Dynlacht(Joseph R),Batuello(Christopher N),L… Radiat Res 2011-10-13

...Rad50 was suppressed. We found that neither Nbs1 nor Rad50 is involved in heat radiosensitization, because a similar amo...

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.

Hohl(Marcel),Kwon(Youngho),Galván(Sandra Muñ… Nat Struct Mol Biol 2011-11-21

...Rad50 hook domain, which are linked by a long and extended Rad50 coiled-coil domain. In this study, we constructed rad50...

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface …

Williams(Gareth J),Williams(R Scott),William… Nat Struct Mol Biol 2011-06-03

...Rad50 complexes define the Mre11 2-helix Rad50 binding domain (RBD) that forms a four-helix interface with Rad50 coiled ...

Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early an…

Soares(Daniele G),Battistella(Aude),Rocca(Cé… Biochem J 2011-08-30

...Rad50-Nbs1) nor ATM (ataxia-telangiectasia mutated), contributes to the initial response to S23906. Interestingly, genet...

Crystal structure of the Mre11-Rad50-ATPγS complex: understanding the interplay…

Lim(Hye Seong),Kim(Jin Seok),Park(Young Bong… Genes Dev 2011-07-06

...Rad50, we determined the crystal structure of the Mre11-Rad50-ATPγS complex. Mre11 brings the two Rad50 molecules into c...

Effect of rad50 mutation on illegitimate recombination in Saccharomyces cerevis…

Chan(Cecilia Y),Zhu(Jie),Schiestl(Robert H) Mol Genet Genomics 2011-09-01

...Rad50 might have a role in protecting free ends of double-strand breaks. In contrast to the rad50∆ mutant, the rad50S mu...

The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-…

Lammens(Katja),Bemeleit(Derk J),Möckel(Carol… Cell 2011-05-27

...Rad50 molecules, a form suited for sensing obstructed breaks. The Mre11 C-terminal helix-loop-helix domain binds Rad50 a...

ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and…

Gatei(Magtouf),Jakob(Burkhard),Chen(Philip),… J Biol Chem 2011-12-05

...Rad50 in that response is evident from the recent description of a patient with Rad50 deficiency characterized by chromo...

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