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Emerging mitotic inhibitors for non-small cell carcinoma.

Casaluce(Francesca),Sgambato(Assunta),Maione… Expert Opin Emerg Drugs 2013-08-21

Mitosis is the key event of the cell cycle, and microtubules play an important part in an array of cellular functions be...

New centromere autoantigens identified in systemic sclerosis using centromere p…

Song(Guang),Hu(Chaojun),Zhu(Heng),Wang(Li),Z… J Rheumatol 2013-10-29

To identify novel centromere protein (CENP) targets of anticentromere antibodies (ACA), and to investigate their associa...

The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore…

Akiyoshi(Bungo),Nelson(Christian R),Duggan(N… PLoS Genet 2013-06-13

The kinetochore is the macromolecular complex that assembles onto centromeric DNA and orchestrates the segregation of du...

Beclin-1 is required for chromosome congression and proper outer kinetochore as…

Frémont(Stéphane),Gérard(Annabelle),Galloux(… EMBO Rep 2013-09-19

The functions of Beclin-1 in macroautophagy, tumorigenesis and cytokinesis are thought to be mediated by its association...

Chromosome engineering allows the efficient isolation of vertebrate neocentrome…

Shang(Wei-Hao),Hori(Tetsuya),Martins(Nuno M … Dev Cell 2013-06-04

Centromeres are specified by sequence-independent epigenetic mechanisms in most organisms. Rarely, centromere reposition...

Dimerization of the CENP-A assembly factor HJURP is required for centromeric nu…

Zasadzińska(Ewelina),Barnhart-Dailey(Meghan … EMBO J 2013-09-30

The epigenetic mark of the centromere is thought to be a unique centromeric nucleosome that contains the histone H3 vari...

The octamer is the major form of CENP-A nucleosomes at human centromeres.

Hasson(Dan),Panchenko(Tanya),Salimian(Kevan … Nat Struct Mol Biol 2013-08-12

The centromere is the chromosomal locus that ensures fidelity in genome transmission at cell division. Centromere protei...

CENP-A confers a reduction in height on octameric nucleosomes.

Miell(Matthew D D),Fuller(Colin J),Guse(Anni… Nat Struct Mol Biol 2013-08-12

Nucleosomes with histone H3 replaced by CENP-A direct kinetochore assembly. CENP-A nucleosomes from human and Drosophila...

Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin i…

Goutte-Gattat(Damien),Shuaib(Muhammad),Ouara… Proc Natl Acad Sci U S A 2013-08-06

The role of the mitotic phosphorylation of the amino (NH2) terminus of Centromere Protein A (CENP-A), the histone varian...

Plasticity and epigenetic inheritance of centromere-specific histone H3 (CENP-A…

Yao(Jianhui),Liu(Xingkun),Sakuno(Takeshi),Li… J Biol Chem 2013-09-09

Nucleosomes containing the specific histone H3 variant CENP-A mark the centromere locus on each chromatin and initiate k...

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