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L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells throu…

Cheng(Lin),Wu(Qiulian),Huang(Zhi),Guryanova(… EMBO J 2011-05-05

...RAD50-NBS1 (MRN) complex that activates ataxia telangiectasia mutated (ATM) kinase and early checkpoint response. Ectopi...

Distinct roles of the ATR kinase and the Mre11-Rad50-Nbs1 complex in the mainte…

Amiard(Simon),Charbonnel(Cyril),Allain(Elisa… Plant Cell 2011-02-07

...Rad50-Nbs1 (MRN) complex is the first sensor of double-strand breaks, its role in double-strand break (DSB) signaling is...

Replication-dependent γ-H2AX formation is involved in docetaxel-induced apoptos…

Zhang(Feng),Zhang(Tao),Qu(Yang),Jiang(Tao),C… Oncol Rep 2011-02-18

...Rad50, were detected. These data show, for the first time, that the induction of apoptosis by docetaxel requires DNA rep...

Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-lik…

Matsumoto(Yoshiyuki),Miyamoto(Tatsuo),Sakamo… DNA Repair (Amst) 2011-06-20

...RAD50/NBS1 protein complex, however deficiency of either protein does not result in the same clinical features. Mutation...

DNA end resection--unraveling the tail.

Mimitou(Eleni P),Symington(Lorraine S) DNA Repair (Amst) 2011-06-20

...Rad50-Xrs2 complex and Sae2, while the second step employs the exonuclease Exo1 and/or the helicase-topoisomerase comple...

Pathology of hereditary breast cancer.

van der Groep(Petra),van der Wall(Elsken),va… Cell Oncol (Dordr) 2011-07-22

...RAD50, BRIP1 and PALB2 have been described to be high or moderate penetrance breast cancer susceptibility genes, all con...

Genetic analysis of DNA repair in the hyperthermophilic archaeon, Thermococcus …

Fujikane(Ryosuke),Ishino(Sonoko),Ishino(Yosh… Genes Genet Syst 2011-03-30

...rad50, mre11, herA, nurA, and xpg/fen1 genes. Phenotypic analyses of the gene-disrupted strains showed that the xpb and ...

The MRE11 complex: starting from the ends.

Stracker(Travis H),Petrini(John H J) Nat Rev Mol Cell Biol 2011-02-16

...RAD50 and Nijmegen breakage syndrome 1 (NBS1; also known as nibrin) proteins is central to the DDR, and recent insights ...

Investigation of the functional link between ATM and NBS1 in the DNA damage res…

Dar(Inbal),Yosha(Galit),Elfassy(Ronen),Galro… J Biol Chem 2011-07-14

...RAD50/NBS1 (MRN) complex, which plays a major role in the early phase of the complex cellular response to double strand ...

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machiner…

Nimonkar(Amitabh V),Genschel(Jochen),Kinoshi… Genes Dev 2011-04-27

...RAD50, and NBS1 (MRN); and Replication protein A (RPA). Resection occurs via two routes. In one, BLM and DNA2 physically...

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