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Copy number alteration profiling facilitates differential diagnosis between oss…

Ma(M),Liu(L),Shi(R),Zhang(J),Li(X),Li(X),Bai… Int J Oral Sci 2021-00-30

...AIMP2, MDM2, and CDK4) with amplified expression, which was consistent with the copy number changes. We further confirme...

Methionyl-tRNA synthetase and aminoacyl-tRNA synthetases interacting multi-func…

Kim(T),Lee(K),Nahm(JH),Kim(EY),Lee(SH),Chang… Am J Cancer Res 2021-00-00

...AIMP2-DX2 (0.891 vs. 0.829, P = 0.003), cytology/MARS/pan-CK (0.916 vs. 0.829, P < 0.001), and cytology/AIMP2-DX2/pan-CK...

Lewy body-associated proteins: victims, instigators, or innocent bystanders? Th…

Lashuel(HA),Novello(S) Neurobiol Dis 2021-00-00

...AIMP2 aggregation, and reexamine the role of AIMP2 in regulating aSyn inclusion formation and clearance and aSyn-induced...

Identification of sixteen novel candidate genes for late onset Parkinson&#x27;s dise…

Gialluisi(A),Reccia(MG),Modugno(N),Nutile(T)… Mol Neurodegener 2021-00-21

...AIMP2, CHMP1A, GIPC1, HMOX2, HSPA8, IMMT, KIF21B, KIF24, MAN2C1, RHOT2, SLC25A39, SPTBN1, TMEM175, TOMM22, TVP23A and ZS...

Is Methionyl-tRNA Synthetase Applicable as a Diagnostic Marker for Lung Cancer …

Lee(K),Oh(M),Lee(KS),Cha(YJ),Chang(YS) Diagnostics (Basel) 2021-10-03

...AIMP2) with an exon 2 deletion (AIMP2-DX2) are known to be overexpressed in lung cancer. However, their role as diagnost...

Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2-Deplete…

Kim(DG),Huddar(S),Lim(S),Kong(J),Lee(Y),Park… J Pharmacol Exp Ther 2021-12-00

...AIMP2-DX2 proteins and direct binding clash between AIMP2-DX2 and HSP70. The compound reduced the level of AIMP2-DX2 in ...

Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2…

Sivaraman(A),Kim(DG),Bhattarai(D),Kim(M),Lee… J Med Chem 2020-00-28

AIMP2-DX2, a splicing variant of AIMP2, is up-regulated in lung cancer, possesses oncogenic activity, and results in tum...

Structural insight into the interaction between p53 TAD1 and AIMP2-DX2 by NMR.

Cho(HY),Jha(R),Mushtaq(AU),Oh(SH),Jeon(YH) Biochem Biophys Res Commun 2020-00-30

...AIMP2 lacking exon2, AIMP2-DX2, compromises the pro-apoptotic activity and anti-proliferative activities of the AIMP2 by...

2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Inter…

Lee(S),Kim(DG),Kim(K),Kim(T),Lim(S),Kong(H),… J Med Chem 2020-00-23

...AIMP2-DX2 rather than WI-26 cells and AIMP2. Aminophenylpyrimidine 3 offers possible therapeutic potential in the treatm...

Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.

Lim(S),Cho(HY),Kim(DG),Roh(Y),Son(SY),Mushta… Nat Chem Biol 2020-00-00

...AIMP2-DX2, via its substrate-binding domain, thus blocking the Siah1-dependent ubiquitination of AIMP2-DX2. AIMP2-DX2-in...

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