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Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: T…

Truong(PH),Ciccotosto(GD),Cappai(R) Neurochem Res 2019-06-00

...APLP2). APP and APLP2 share a high degree of similarity, and have overlapping patterns of spatial and temporal expressio...

Amyloid precursor-like protein 2 cleavage contributes to neuronal intranuclear …

Takahashi-Fujigasaki(J),Breidert(T),Fujigasa… Neurobiol Dis 2011-01-00

...APLP2) was identified as a partner protein for ataxin-7. APLP2, belonging to the APP gene family, undergoes secretase an...

Identification and expression of the first nonmammalian amyloid-beta precursor-…

Collin(RW),van Strien(D),Leunissen(JA),Marte… Eur J Biochem 2004-05-00

...APLP2 protein in the South African claw-toed frog Xenopus laevis. The identity between the Xenopus and mammalian APLP2 p...

The amyloid precursor-like protein 2 associates with the major histocompatibili…

Sester(M),Feuerbach(D),Frank(R),Preckel(T),G… J Biol Chem 2000-02-04

...APLP2. We further show that the APLP2/K(d) association does not require the physical presence of E3/19K. Thus, APLP2 exh...

Mice with combined gene knock-outs reveal essential and partially redundant fun…

Heber(S),Herms(J),Gajic(V),Hainfellner(J),Ag… J Neurosci 2000-11-01

...APLP2(-/-)/APLP1(-/-) and APLP2(-/-)/APP(-/-) mice proved lethal early postnatally. Surprisingly, APLP1(-/-)/APP(-/-) mi...

A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amylo…

Cong(R),Li(Y),Biemesderfer(D) Am J Physiol Cell Physiol 2011-06-00

...APLP2-specific short hairpin RNA (shRNA) in OKP cells. Cells expressing the APLP2 shRNA showed >80% knock down of APLP2 ...

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 k…

White(AR),Reyes(R),Mercer(JF),Camakaris(J),Z… Brain Res 1999-09-25

...APLP2. The APP and APLP2 molecules contain metal binding sites for copper and zinc. The zinc binding domain (ZnBD) is be...

BACE (beta-secretase) modulates the processing of APLP2 in vivo.

Pastorino(L),Ikin(AF),Lamprianou(S),Vacaress… Mol Cell Neurosci 2004-04-00

...APLP2. To this end, we developed BACE knockout mice with a targeted insertion of the gene for beta-galactosidase. BACE a...

Amyloid precursor-like protein 2 increases the endocytosis, instability, and tu…

Tuli(A),Sharma(M),McIlhaney(MM),Talmadge(JE)… J Immunol 2008-08-01

...APLP2) associates with the folded form of the MHC class I molecule K(d). In the current study, APLP2 was found to associ...

Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angioge…

Kawase(H),Liu(S),Kurz(S),Bengelsdorff(V),Bon… Sci Adv 2026-05-22

...APLP2 into the soluble forms APPsα and APLP2sα. Loss of endothelial APP and APLP2 led to decreased neovascularization as...

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