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Cold atmospheric plasma, a new strategy to induce senescence in melanoma cells.

Arndt(Stephanie),Wacker(Eva),Li(Yang-Fang),S… Exp Dermatol 2013-09-16

...Rad17 phosphorylation of Cytochrome c release and activation of Caspase-3. Interestingly, using lower CAP doses with 1 m...

The mechanism of nucleotide excision repair-mediated UV-induced mutagenesis in …

Kozmin(Stanislav G),Jinks-Robertson(Sue) Genetics 2013-08-15

...Rad17, Mec3, Ddc1, Mec1, and Rad9) were required for the production of two-strand mutations. There was no involvement, h...

Lagging strand maturation factor Dna2 is a component of the replication checkpo…

Kumar(Sandeep),Burgers(Peter M) Genes Dev 2013-03-22

...Rad17 and human Rad9-Rad1-Hus1) and Dpb11, the ortholog of human TopBP1. A triple mutant that eliminates the checkpoint ...

NBS1 directly activates ATR independently of MRE11 and TOPBP1.

Kobayashi(Masahiko),Hayashi(Naoyuki),Takata(… Genes Cells 2013-08-05

...Rad17 knockout cells, and the expression of the ATR activation domain of TOPBP1 fused to PCNA induces ATR activation in ...

Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in …

Zhou(Zhuan),Jing(Chao),Zhang(Liyong),Takeo(F… J Biol Chem 2013-09-06

...Rad17 in various types of breast cancer cell lines as well as human breast cancer tissues. We observed that Rad17 protei...

Exon-skipping strategy by ratio modulation between cytoprotective versus pro-ap…

Essabbani(Abdellatif),Garcia(Luis),Zonetti(M… PLoS One 2013-08-09

...Rad17 expression which could be a key mechanism in sensitizing cells to cell death. In conclusion, this is the first rep...

Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation…

Tuul(Munkhbold),Kitao(Hiroyuki),Iimori(Makot… PLoS One 2013-07-15

...Rad17, TopBP1 and Claspin. Activation of the ATR-Chk1 pathway by heat, however, was not associated with FancD2 monoubiqu...

Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.

Shiotani(Bunsyo),Nguyen(Hai Dang),Håkansson(… Cell Rep 2013-12-16

...Rad17-independent but Nbs1-dependent manner in vivo and in vitro. Importantly, the role of Nbs1 in RPA32 phosphorylation...

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk…

Lee(Joon),Dunphy(William G) Mol Biol Cell 2013-11-14

...Rad17 and MRN leads to a further, essentially complete, reduction in the activation of Chk1. Thus, Rad17 and MRN act in ...

A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase …

Tomida(Junya),Itaya(Akiko),Shigechi(Tomoko),… Nucleic Acids Res 2013-11-04

...RAD17 and TOPBP1 is largely dispensable for the FA pathway activation. Indeed DT40 mutant cells lacking both RAD17 and F...

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