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Causal Effects and Single-Cell Microenvironmental Implications of Germline Vari…

Sheng(B),Wang(J) Hum Mutat None

...RAD50 that genetically predicted increased CRC risk. Single-cell analysis was subsequently performed to evaluate the cel...

D-Ribose-L-Cysteine mitigates copper-induced testicular toxicity in mice throug…

Omeiza(NA),Omeiza(FR),Chimezie(J),Ogunyemi(O… J Trace Elem Med Biol 2026-08-00

...RAD50), suggesting coordinated regulation of oxidative stress, inflammatory, apoptotic, and DNA repair pathways. Taken t...

Insights into the function and structure of the R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D…

Mohamed(M),Wu(R),Houry(WA) Cell Stress Chaperones 2026-07-00

...RAD50-NBS1 (MRN) complex. Additionally, the role of R2TP in ciliogenesis, circadian rhythm regulation, and transcription...

AI-based pathomics model predicts regulatory T cell infiltration and radiothera…

Peng(S),Chen(J),Wang(X),Wang(X),Yue(Q),Lan(H… Front Immunol None

...RAD50, suggesting a potential association with radiotherapy response. This AI-based pathomics framework offers a robust ...

MRE11 Deficiency Occurs in a Small Group of Cancers from Various Different Tumo…

Reiswich(V),Recksiek(H),Möller(K),Lutz(F),Vi… Diagnostics (Basel) 2026-06-24

...RAD50/NBS1 (MRN) complex. Cancers with reduced MRE11 expression have been suggested to be more sensitive to radio-chemot...

Pharmacologic inhibition of RBBP4/p300-mediated homologous recombination activi…

Mapunda(JA),Laverty(DJ),Aziz(F),Le(A),Sangar… Neurooncol Adv None

...RAD50, BRCA1, BARD1, BRIP1, and FIGNL1), with RAD51 and BRIP1 correlating strongly with RBBP4 and p300. Silencing RBBP4 ...

Alternative Lengthening of Telomeres is dependent on RAD52 and RAD51 gene funct…

Itriago(H),Cohn(M) G3 (Bethesda) 2026-06-16

...RAD50 and RAD59 genes are not essential. This implies that the N. castellii ALT mechanism is dependent on homologous rec...

Thyroid cancer and double-strand DNA break repair: The potential role of the MR…

Gubbi(S),Moorthy(V),Grover(A),Al-Souri(D),Bi… J Clin Transl Endocrinol 2026-08-00

...RAD50-NBS1 (MRN) complex is a key mediator of homologous recombination mode of double-strand break repair, and its role ...

Utilization of whole exome sequencing to identify hereditary mutations in Pales…

Qutob(N),Hindiyeh(M),Zahdeh(F),Alian(A),Thaw… Front Genet None

...RAD50 (c.2524+3A>G) in Family I, a truncating MSH4 variant (c.328C>T; p.R110X) and a missense STAT6 variant (c.1216C>G; ...

Basic-patch mutations in bacteriophage T4 Rad50 uncouple ATPase activation from…

Teklemariam(TA),Finnerty(RM),Coats(JB),Nelso… Biosci Rep 2026-08-19

The Mre11/Rad50 (MR) complex uses adenosine triphosphate (ATP) binding and hydrolysis to coordinate the recognition and ...

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