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A Breast Tissue Protein Expression Profile Contributing to Early Parity-Induc...

Gutierrez(Christina Marie),Lopez-Valdez(Re... Cell Physiol Biochem 2016-08-31

...RAD52, BRCA1, MAPKAPK-2, ATF-1, ICAM1, and NF-kappaB compared to late and nulli parity.,Early parity reduces basal cell ...

Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicin...

Chandramouly(Gurushankar),McDevitt(Shane),... Chem Biol 2016-09-07

...RAD52 causes synthetic lethality in BRCA-deficient cells. Yet pharmacological inhibition of RAD52, which binds single-st...

The spliceosome-associated protein Nrl1 suppresses homologous recombination-d...

Aronica(Lucia),Kasparek(Torben),Ruchman(Da... Nucleic Acids Res 2016-07-25

...Rad52 for their formation. Together, our findings support a model in which R-loop accumulation and subsequent DNA damage...

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Functi...

Buser(Raymond),Kellner(Vanessa),Melnik(And... PLoS Genet 2016-07-19

...Rad52-dependent mechanism. Our results suggest that the Rtt101(Mms22) E3 ligase does not induce Mrc1 degradation, but sp...

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Sele...

Sullivan(Katherine),Cramer-Morales(Kimberl... PLoS One 2016-08-09

...RAD52. Thirty six lead candidate compounds were identified that were predicted to interfere with RAD52 -DNA binding. Fur...

DNA polymerases δ and λ cooperate in repairing double-strand breaks by microh...

Meyer(Damon),Fu(Becky Xu Hua),Heyer(Wolf-D... Proc Natl Acad Sci U S A 2016-06-03

...Rad52 and Rad51, suppressed MMEJ in this system, suggesting a competition between HR and MMEJ for the repair of a DSB. I...

Impaired mitochondrial Fe-S cluster biogenesis activates the DNA damage respo...

Pijuan(Jordi),María(Carlos),Herrero(Enriqu... J Cell Sci 2016-09-21

...Rad52-associated DNA repair foci and a higher phosphorylated state of γH2A histone, altogether supporting the presence o...

Invasive oral cancer stem cells display resistance to ionising radiation.

Gemenetzidis(Emilios),Gammon(Luke),Biddle(... Oncotarget 2016-10-07

...RAD52, XLF, and a significantly faster rate of DNA double-strand-breaks clearance 24 hours following IR. By visually ide...

Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.

Gadaleta(Mariana C),Das(Mukund M),Tanizawa... PLoS Genet 2016-08-03

...Rad52 recombinase and more frequent amplification of telomere/subtelomeres, reminiscent of tumor cells that utilize the ...

Recombination-Mediated Telomere Maintenance in Saccharomyces cerevisiae Is No...

van Mourik(Paula M),de Jong(Jannie),Agpalo... PLoS One 2016-08-08

...Rad52-dependent homologous recombination and Pol32-dependent break-induced replication. There are two main types of surv...

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