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RGS4 inhibits signaling by group I metabotropic glutamate receptors.

Saugstad(J A),Marino(M J),Folk(J A),Hepler... J Neurosci 1998-02-06

...RGS4 to regulate group I mGluR responses. In Xenopus oocytes, purified RGS4 virtually abolishes the mGluR1a- and mGluR5a...

Mechanism of RGS4, a GTPase-activating protein for G protein alpha subunits.

Srinivasa(S P),Watson(N),Overton(M C),Blum... J Biol Chem 1998-02-12

...RGS4, a GAP for heterotrimeric G protein alpha subunits, stimulates GTP hydrolysis. Many of the residues of RGS4 that in...

RGS7 attenuates signal transduction through the G(alpha q) family of heterotr...

Shuey(D J),Betty(M),Jones(P G),Khawaja(X Z... J Neurochem 1998-05-18

...RGS4 are reported to be expressed predominantly in brain, and in situ hybridization studies have revealed similarities i...

Plasma membrane localization is required for RGS4 function in Saccharomyces c...

Srinivasa(S P),Bernstein(L S),Blumer(K J),... Proc Natl Acad Sci U S A 1998-06-19

...RGS4 (Delta1-33). Thus, plasma membrane localization is tightly coupled with the ability of RGS4 to inhibit signaling. F...

A point mutation in Galphao and Galphai1 blocks interaction with regulator of...

Lan(K L),Sarvazyan(N A),Taussig(R),Mackenz... J Biol Chem 1998-06-25

...RGS4. The G --> S mutant proteins showed a greater than 30-100-fold lower affinity for RGS4. Thus, we have defined the m...

RGS3 and RGS4 are GTPase activating proteins in the heart.

Zhang(S),Watson(N),Zahner(J),Rottman(J N),... J Mol Cell Cardiol 1998-05-28

...RGS4 mRNAs and proteins were detected in adult myocardium. RGS3 and RGS4 gene expression was markedly enhanced in two mo...

Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasm...

Druey(K M),Sullivan(B M),Brown(D),Fischer(... J Biol Chem 1998-08-13

...RGS4 and a non-Gialpha-binding mutant (L159F) to the plasma membrane. These data suggest that RGS4 may be recruited to t...

Specific involvement of G proteins in regulation of serum response factor-med...

Mao(J),Yuan(H),Xie(W),Simon(M I),Wu(D) J Biol Chem 1998-11-06

...RGS4, or Axin was able to inhibit Galpha12 and Galpha13-mediated SRF activation. And RGS12, but not other RGS proteins, ...

Regulation of chemotactic and proadhesive responses to chemoattractant recept...

Bowman(E P),Campbell(J J),Druey(K M),Sches... J Biol Chem 1998-11-12

...RGS4 inhibits chemoattractant-induced migration. In contrast, RGS2, a regulator of Galphaq activity, had no effect on ce...

Activation of transducin guanosine triphosphatase by two proteins of the RGS ...

Nekrasova(E R),Berman(D M),Rustandi(R R),H... Biochemistry 1997-07-21

...RGS4 and G alpha interacting protein (GAIP). RGS4, being at least 5-fold more potent than GAIP, stimulates the rate of t...

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