Popov(S),Yu(K),Kozasa(T),Wilkie(T M) Proc Natl Acad Sci U S A 1997-08-05

...RGS4, RGS10, and GAIP retain GTPase accelerating activity with the Gi class substrates Gialpha1, Goalpha, and Gzalpha in...

Gold(S J),Ni(Y G),Dohlman(H G),Nestler(E J... J Neurosci 1997-10-23

...RGS4, RGS7, RGS8, RGS9, and RGS10 mRNAs, are densely expressed in brain, whereas the other subtypes (RGS3, RGS5, RGS6, a...

Doupnik(C A),Davidson(N),Lester(H A),Kofuj... Proc Natl Acad Sci U S A 1997-10-21

...RGS4, but not RGS2. For the brain-expressed RGS4 isoform, neither the current amplitude nor the steady-state agonist dos...

Tu(Y),Wang(J),Ross(E M) Science 1997-11-24

...RGS4. The extent of inhibition of Gz GAP, GAIP, RGS4, and RGS10 correlated roughly with their intrinsic GAP activities f...

Huang(C),Hepler(J R),Gilman(A G),Mumby(S M... Proc Natl Acad Sci U S A 1997-07-10

...RGS4 and GAIP both attenuated Gi-mediated inhibition of cAMP synthesis. RGS4 was more effective than GAIP in blocking Gq...

Yan(Y),Chi(P P),Bourne(H R) J Biol Chem 1997-06-02

...RGS4 in COS-7 cells. Pertussis toxin, which uncouples Gi from receptors, blocked MAPK activation by the D2 dopamine rece...

Tesmer(J J),Berman(D M),Gilman(A G),Sprang... Cell 1997-05-15

...RGS4 complexed with G(i alpha1)-Mg2+-GDP-AlF4 . Only the core domain of RGS4 is visible in the crystal. The core domain ...

Hepler(J R),Berman(D M),Gilman(A G),Kozasa(T) Proc Natl Acad Sci U S A 1997-03-06

...RGS4 and GAIP, also act as GAPs for Gq alpha, the G alpha protein responsible for activation of phospholipase C beta. Fu...

Berman(D M),Wilkie(T M),Gilman(A G) Cell 1996-09-26

...RGS4, are GTPase-activating proteins (GAPs), accelerating the rate of GTP hydrolysis by Gi alpha 1 at least 40-fold. All...

Watson(N),Linder(M E),Druey(K M),Kehrl(J H... Nature 1996-10-03

...RGS4 and GAIP (for G alpha-interacting protein) bind specifically and tightly to G alphai and G alpha0 in cell membranes...