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Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical…

Lock(Richard B),Carol(Hernan),Morton(Christo… Pediatr Blood Cancer 2012-05-16

The centromere kinesin motor protein CENP-E plays a crucial role in mitosis, and is an appealing molecular target in can...

HJURP uses distinct CENP-A surfaces to recognize and to stabilize CENP-A/histon…

Bassett(Emily A),DeNizio(Jamie),Barnhart-Dai… Dev Cell 2012-06-18

Centromeres are defined by the presence of chromatin containing the histone H3 variant, CENP-A, whose assembly into nucl...

Molecular underpinnings of centromere identity and maintenance.

Sekulic(Nikolina),Black(Ben E) Trends Biochem Sci 2012-10-01

Centromeres direct faithful chromosome inheritance at cell division but are not defined by a conserved DNA sequence. Ins...

Replicating centromeric chromatin: spatial and temporal control of CENP-A assem…

Nechemia-Arbely(Yael),Fachinetti(Daniele),Cl… Exp Cell Res 2012-08-23

The centromere is the fundamental unit for insuring chromosome inheritance. This complex region has a distinct type of c...

CENP-T proteins are conserved centromere receptors of the Ndc80 complex.

Schleiffer(Alexander),Maier(Michael),Litos(G… Nat Cell Biol 2012-08-13

Centromeres direct the assembly of kinetochores, microtubule-attachment sites that allow chromosome segregation on the m...

T time for point centromeres.

Gascoigne(Karen E),Cheeseman(Iain M) Nat Cell Biol 2012-08-13

The diverse nature of eukaryotic centromere structure has led to a prevailing view that the kinetochore-chromatin interf...

Formation of a centromere-specific chromatin structure.

Fukagawa(Tatsuo) Epigenetics 2012-11-12

The kinetochore is formed on centromeric DNA as a key interface with microtubules from the mitotic spindle to achieve ac...

Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome…

Samel(Anke),Cuomo(Alessandro),Bonaldi(Tizian… Proc Natl Acad Sci U S A 2012-08-27

Centromeres of eukaryotic chromosomes mark the site for kinetochore formation and microtubule attachment and are essenti...

A coordinated interdependent protein circuitry stabilizes the kinetochore ensem…

Thakur(Jitendra),Sanyal(Kaustuv) PLoS Genet 2012-09-26

Unlike most eukaryotes, a kinetochore is fully assembled early in the cell cycle in budding yeasts Saccharomyces cerevis...

Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A lo…

Kim(Ik Soo),Lee(Minkyoung),Park(Koog Chan),J… Mol Cell 2012-07-23

The Mis18 complex has been identified as a critical factor for the centromeric localization of a histone H3 variant, cen...

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