Chromosome segregation is an essential process for nuclear and cell division. The microtubule cytoskeleton, molecular mo...
The centromere is a specialized chromosomal region that directs the formation of the kinetochore, a huge protein assemb...
Semi-conservative segregation of nucleosomes to sister chromatids during DNA replication creates gaps that must be fille...
A specialized nucleosome is a component of all eukaryotic kinetochores. The core of this nucleosome contains a centromer...
The 'McClintock mechanism' of chromosome breakage and centromere misdivision, in which a deleted chromosome with its con...
Centromeric protein A (CENP-A) is the epigenetic mark of centromeres. CENP-A replenishment is necessary in each cell cyc...
Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer of the cervix. In the...
Centromeres provide a region of chromatin upon which kinetochores are assembled in mitosis. Centromeric protein C (CENP-...
Kinetochores are proteinaceous scaffolds implicated in the formation of load-bearing attachments of chromosomes to micro...
Accurate chromosome segregation requires assembly of the multiprotein kinetochore complex at centromeres. Although prior...
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