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The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in...

Piggott(Leslie A),Bauman(Andrea L),Scott(J... Proc Natl Acad Sci U S A 2008-10-09

...AKAP9/Yotiao displays unique specificity for interaction and the regulation of a variety of AC isoforms. Yotiao inhibits...

BRAF kinase activation via chromosomal rearrangement in radiation-induced and...

Ciampi(Raffaele),Knauf(Jeffrey A),Rabes(Ha... Cell Cycle 2006-05-05

...AKAP9-BRAF, contains the intact kinase domain and lacks the autoinhibitory N-terminal portion of BRAF. It exhibited cons...

Alterations of the BRAF gene in thyroid tumors.

Ciampi(Raffaele),Nikiforov(Yuri E) Endocr Pathol 2006-01-17

...AKAP9-BRAF fusion. It is rare in sporadic papillary carcinomas and is more common in tumors associated with radiation ex...

Search for low penetrance alleles for colorectal cancer through a scan of 146...

Webb(Emily L),Rudd(Matthew F),Sellick(Gabr... Hum Mol Genet 2006-12-21

...AKAP9 M463I remained significantly associated with CRC risk after stringent adjustment for multiple testing. Further SNP...

BRAF mutation and AKAP9 expression in sporadic papillary thyroid carcinomas.

Lee(Ju-Han),Lee(Eung Seok),Kim(Young-Sik),... Pathology 2006-08-08

...AKAP9 protein by immunohistochemistry. The AKAP9 protein was seen as a single perinuclear dot in all the PTCs. Therefore...

Variants in the GH-IGF axis confer susceptibility to lung cancer.

Rudd(Matthew F),Webb(Emily L),Matakidou(At... Genome Res 2006-07-13

...AKAP9 M463I (OR=1.32, P=1.0x10(-4)) and GHR P495T (OR=12.98, P=0.0019). Significant associations were also detected for ...

A new mechanism of BRAF activation in human thyroid papillary carcinomas.

Fusco(Alfredo),Viglietto(Giuseppe),Santoro... J Clin Invest 2005-02-10

...AKAP9) gene with the C-terminal catalytic domain (exons 9-18) of the serine-threonine kinase BRAF. The resulting AKAP9-B...

Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation i...

Ciampi(Raffaele),Knauf(Jeffrey A),Kerler(R... J Clin Invest 2005-02-10

...AKAP9 gene and exons 9-18 of BRAF. The fusion protein contains the protein kinase domain and lacks the autoinhibitory N-...

Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotia...

Tu(Huiping),Tang(Tie-Shan),Wang(Zhengnan),... J Biol Chem 2004-06-10

...AKAP9 (Yotiao) multi-functional PKA anchoring protein. 3) InsP(3)R1-AKAP9 association is mediated via the leucine/isoleu...

Improving the comparative map of porcine chromosome 9 with respect to human c...

Middleton(R),Aldenhoven(J),Chen(Y),Backofe... Cytogenet Genome Res 2004-06-07

...AKAP9, CYP51A1, SGCE, ROBO4, SIAT4C, GLUL, CACNA1E, PTGS2, C1orf16 and ETS1) were mapped to SSC9, while GUSB, CPSF4 and ...

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