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Synthetic heterochromatin bypasses RNAi and centromeric repeats to establish fu…

Kagansky(Alexander),Folco(Hernan Diego),Alme… Science 2009-07-10

In the central domain of fission yeast centromeres, the kinetochore is assembled on CENP-A(Cnp1) nucleosomes. Normally, ...

Centromere assembly requires the direct recognition of CENP-A nucleosomes by CE…

Carroll(Christopher W),Silva(Mariana C C),Go… Nat Cell Biol 2009-07-20

Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere prot...

Characterization of the two centromeric proteins CENP-C and MIS12 in Nicotiana …

Nagaki(Kiyotaka),Kashihara(Kazunari),Murata(… Chromosome Res 2009-12-24

Centromeres play an important role in chromosome transmission in eukaryotes and comprise specific DNA and proteins that ...

Characterization of novel diaryl oxazole-based compounds as potential agents to…

Shaw(Arthur Y),Henderson(Meredith C),Flynn(G… J Pharmacol Exp Ther 2009-11-30

A series of diaryl- and fluorenone-based analogs of the lead compound UA-62784 [4-(5-(4-methoxyphenyl)oxazol-2-yl)-9H-fl...

Integrative analysis of cyclin protein levels identifies cyclin b1 as a classif…

Agarwal(Roshan),Gonzalez-Angulo(Ana-Maria),M… Clin Cancer Res 2009-07-07

We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient out...

The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes c…

Prystowsky(Michael B),Adomako(Alfred),Smith(… J Pathol 2009-09-10

Head and neck squamous cell carcinoma represents a complex set of neoplasms arising in diverse anatomical locations. The...

Focus on the centre: the role of chromatin on the regulation of centromere iden…

Torras-Llort(Mònica),Moreno-Moreno(Olga),Azo… EMBO J 2009-09-16

The centromere is a specialised chromosomal structure that regulates faithful chromosome segregation during cell divisio...

Defects in chromosome congression and mitotic progression in KIF18A-deficient c…

Huang(Ying),Yao(Yixin),Xu(Han-Zhang),Wang(Zh… Cell Cycle 2009-10-27

KIF18A, a molecular motor, is an essential component in the regulation of orderly chromosome congression by attenuation ...

Orchestrating twosome and foursome chromosome parties.

Kalitsis(Paul),Choo(K H Andy) Dev Cell 2009-09-30

The conserved centromere protein C (CENP-C) is indispensable for kinetochore function. Yet its mechanism of action has r...

CENP-C functions as a scaffold for effectors with essential kinetochore functio…

Tanaka(Koichi),Chang(Hui Li),Kagami(Ayano),W… Dev Cell 2009-09-30

The conserved kinetochore protein CENP-C plays a fundamental role in chromosome segregation, but its specific functions ...

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