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Detection and identification of antinuclear antibodies (ANA) in a large communi…

Verstegen(G),Duyck(M C),Meeus(P),Ravelingien… Acta Clin Belg 2009-12-08

Antinuclear antibodies (ANA) and their identification are important diagnostic tools in rheumatic diseases. We aimed to ...

Characterization of novel diaryl oxazole-based compounds as potential agents to…

Shaw(Arthur Y),Henderson(Meredith C),Flynn(G… J Pharmacol Exp Ther 2009-11-30

A series of diaryl- and fluorenone-based analogs of the lead compound UA-62784 [4-(5-(4-methoxyphenyl)oxazol-2-yl)-9H-fl...

CENP-H-containing complex facilitates centromere deposition of CENP-A in cooper…

Okada(Masahiro),Okawa(Katsuya),Isobe(Toshiak… Mol Biol Cell 2009-12-09

Centromere identity is thought to be determined by epigenetic mechanisms. The centromere-specific histone H3 variant CEN...

Defects in chromosome congression and mitotic progression in KIF18A-deficient c…

Huang(Ying),Yao(Yixin),Xu(Han-Zhang),Wang(Zh… Cell Cycle 2009-10-27

KIF18A, a molecular motor, is an essential component in the regulation of orderly chromosome congression by attenuation ...

Nuclear autoantigen CENP-B transactivation of the epidermal growth factor recep…

Robitaille(Geneviève),Christin(Marie-Soleil)… Arthritis Rheum 2009-10-19

We have previously found that the CENP-B nuclear autoantigen, which is specifically targeted by autoantibodies in the li...

Clinical associations of anti-CENP-B and anti-Scl70 antibody levels measured by…

Volpe(Alessandro),Ruzzenente(Orazio),Caramas… Rheumatol Int 2009-09-24

The aim of this study was to assess the association between anti-CENP-B and anti-Scl70 antibody levels, measured by mult...

LINE retrotransposon RNA is an essential structural and functional epigenetic c…

Chueh(Anderly C),Northrop(Emma L),Brettingha… PLoS Genet 2009-03-16

We have previously identified and characterized the phenomenon of ectopic human centromeres, known as neocentromeres. Hu...

Molecular architecture of the kinetochore-microtubule attachment site is conser…

Joglekar(Ajit P),Bouck(David),Finley(Ken),Li… J Cell Biol 2008-06-03

Point and regional centromeres specify a unique site on each chromosome for kinetochore assembly. The point centromere i...

A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of …

Natsume(Toyoaki),Tsutsui(Yasuhiro),Sutani(Ta… PLoS One 2008-08-19

Specialized chromatin exists at centromeres and must be precisely transmitted during DNA replication. The mechanisms inv...

Audiovestibular manifestations in patients with limited systemic sclerosis and …

Amor-Dorado(Juan C),Arias-Nuñez(Maria C),Mir… Medicine (Baltimore) 2008-07-17

Audiovestibular dysfunction has been reported in patients with connective tissue disease. Systemic sclerosis (SSc; scler...

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