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Nicotine modulates expression of amyloid precursor protein and amyloid precurso…

Gutala(R),Wang(J),Hwang(YY),Haq(R),Li(MD) Brain Res 2006-06-06

...APLP2), in different brain regions of C57BL/6 mice using a pathway-focused microarray. Our results revealed that nicotin...

Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R tran…

Truong(PH),Crouch(PJ),Hilton(JBW),McLean(CA)… Cell Mol Life Sci 2021-10-00

...APLP2) genes. In the present study, we investigated the role of APLP2 in MND through the examination of human spinal cor...

Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate M…

DeVay(RM),Yamamoto(L),Shelton(DL),Liang(H) PLoS One 2015-00-00

...APLP2 or LDLR is independently sufficient for PCSK9 endocytosis in hepatocytes, while LDL can compete with APLP2 for PCS...

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's…

Wasco(W),Gurubhagavatula(S),Paradis(MD),Roma… Nat Genet 1993-09-00

...APLP2 gene. We show that APLP2 is a close relative of APP and exhibits a very similar pattern of expression in the brain...

Increased gene expression of beta-amyloid precursor protein and its homologues …

Beckman(M),Iverfeldt(K) Neurosci Lett 1997-01-17

...APLP2. Previously it has been shown that APP is subject to regulation by retinoic acid (RA). In this paper we show that ...

Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brai…

Johnston(JA),Norgren(S),Ravid(R),Wasco(W),Wi… Brain Res Mol Brain Res 1996-12-31

...APLP2). Since A beta accumulation can be triggered by factors acting up- or downstream of APP processing, we investigate...

Similar alternative splicing of a non-homologous domain in beta A4-amyloid prot…

Sandbrink(R),Masters(CL),Beyreuther(K) J Biol Chem 1994-05-13

...APLP2/APPH. Analysis of the tissue-specific differential expression of the resulting four APLP2/APPH mRNA isoforms revea...

APP gene family: unique age-associated changes in splicing of Alzheimer's betaA…

Sandbrink(R),Masters(CL),Beyreuther(K) Neurobiol Dis 1994-11-00

...APLP2) is the nearest relative. Analysis of APLP2 expression revealed regulated alternative splicing of the Kunitz prote...

Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1…

Adlerz(L),Beckman(M),Holback(S),Tehranian(R)… Brain Res Mol Brain Res 2003-11-06

...APLP2. The function of these three proteins is not yet fully understood. One of the proposed roles of APP is to promote ...

Generation of conditional null alleles for APP and APLP2.

Mallm(JP),Tschäpe(JA),Hick(M),Filippov(MA),M… Genesis 2010-03-00

...APLP2 remains poorly understood. Previously, we generated APP(-/-) mice that proved viable, whereas APP(-/-)APLP2(-/-) m...

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