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Polymerase epsilon is required to maintain replicative senescence.

Deshpande(Abhyuday M),Ivanova(Iglika G),Rayk… Mol Cell Biol 2011-06-03

...Rad17)-dependent checkpoint pathway, alternates in time with an Mrc1-regulated Pol ε resynthesis of a short, double-stra...

Sustained and rapid chromosome movements are critical for chromosome pairing an…

Sonntag Brown(Megan),Zanders(Sarah),Alani(Er… Genetics 2011-08-17

...rad17Δ) in the Rad17 checkpoint protein suppresses the delay but confers a severe spore viability defect. csm4-3 mutants...

Characterization of functional domains in human Claspin.

Serçin(Ozdemirhan),Kemp(Michael G) Cell Cycle 2011-09-28

...Rad17-Replication Factor C (RFC). We conclude that multiple protein-DNA and protein-protein interactions may be importan...

Phenotypic enhancement of thymidylate synthetase pathway inhibitors following a…

Taricani(Lorena),Shanahan(Frances),Pierce(Ro… Cell Cycle 2011-05-02

...Rad17, Rad9 ATR, ATM and DNA-PK checkpoint/sensor proteins appears primarily epistatic to Neil1. These data suggest Neil...

A new in vitro system for activating the cell cycle checkpoint.

Wang(Jingna),Engle(Staci),Zhang(Youwei) Cell Cycle 2011-07-04

...Rad17, and ATM itself. These phosphorylation events highly mimic those occurring in cells when treated with DNA damaging...

Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase.

Navadgi-Patil(Vasundhara M),Burgers(Peter M) Biochem Soc Trans 2011-07-01

...Rad17 and Mec3 in S. cerevisiae; Ddc1-Mec3-Rad17) and the DNA replication initiation factor Dpb11 (human TopBP1) are the...

hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced…

Pabla(Navjotsingh),Ma(Zhengwei),McIlhatton(M… J Biol Chem 2011-06-09

...Rad17, and the Rad9-Hus1-Rad1 protein complex. Together the results support a hMSH2-dependent pathway of ATR activation ...

Effect of Genes Controlling Radiation Sensitivity on Chemically Induced Mutatio…

Prakash(L) Genetics 2010-06-28

...rad17, rad18, rad22, rev1, rev2 and rev3 lowered NQO reversion while rad1, rad2, rad3, rad4, rad10, rad12 and rad16 incr...

The Saccharomyces cerevisiae RAD9, RAD17 and RAD24 genes are required for suppr…

Murakami-Sekimata(Akiko),Huang(Dongqing),Pie… DNA Repair (Amst) 2010-09-16

...Rad17 and Rad24. Here, we describe a novel hypermutable phenotype for rad9Delta, rad17Delta and rad24Delta cells in resp...

Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery …

Zhang(Liyong),Park(Chi-Hoon),Wu(Jing),Kim(Hy… EMBO J 2010-06-14

...Rad17 oscillation is mediated by Cdh1/APC, a ubiquitin-protein ligase. Studies using a degradation-resistant Rad17 mutan...

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