Several genetic aberrations and gene expression changes have been shown to occur when cells are exposed to various types...
Chromosome movements in mitosis are orchestrated by dynamic interactions between spindle microtubules and the kinetochor...
Mif2p is the budding-yeast orthologue of the mammalian centromere-binding protein CENP-C. We have mapped domains of Sacc...
The spindle checkpoint ensures the accurate segregation of chromosomes by monitoring the status of kinetochore attachmen...
A defining feature of centromeres is the presence of the histone H3 variant CENP-A(Cnp1). It is not known how CENP-A(Cnp...
Heterochromatin is defined by distinct posttranslational modifications on histones, such as methylation of histone H3 at...
Transposable elements and their remnants constitute a substantial fraction of eukaryotic genomes. Host genomes have evol...
We previously identified a multisubunit complex (CENP-H/I complex) in kinetochores from human and chicken cells. We show...
The eukaryote centromere was initially defined cytologically as the primary constriction on vertebrate chromosomes and f...
DNA segregation in mammalian cells during mitosis is an essential cellular process that is mediated by a specific subchr...
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