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Gene expression profiling of breast cells induced by X-rays and heavy ions.

Roy(D),Guida(P),Zhou(G),Echiburu-Chau(C),Cal… Int J Mol Med 2008-07-08

Several genetic aberrations and gene expression changes have been shown to occur when cells are exposed to various types...

Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of func…

Yang(Yong),Wu(Fang),Ward(Tarsha),Yan(Feng),W… J Biol Chem 2008-11-10

Chromosome movements in mitosis are orchestrated by dynamic interactions between spindle microtubules and the kinetochor...

Structural and functional dissection of Mif2p, a conserved DNA-binding kinetoch…

Cohen(R L),Espelin(C W),De Wulf(P),Sorger(P … Mol Biol Cell 2008-12-01

Mif2p is the budding-yeast orthologue of the mammalian centromere-binding protein CENP-C. We have mapped domains of Sacc...

Ybp2 associates with the central kinetochore of Saccharomyces cerevisiae and me…

Ohkuni(Kentaro),Abdulle(Rashid),Tong(Amy Hin… PLoS One 2008-07-15

The spindle checkpoint ensures the accurate segregation of chromosomes by monitoring the status of kinetochore attachmen...

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its depo…

Dunleavy(Elaine M),Pidoux(Alison L),Monet(Ma… Mol Cell 2008-02-11

A defining feature of centromeres is the presence of the histone H3 variant CENP-A(Cnp1). It is not known how CENP-A(Cnp...

Heterochromatin and RNAi are required to establish CENP-A chromatin at centrome…

Folco(Hernan Diego),Pidoux(Alison L),Urano(T… Science 2008-01-16

Heterochromatin is defined by distinct posttranslational modifications on histones, such as methylation of histone H3 at...

Host genome surveillance for retrotransposons by transposon-derived proteins.

Cam(Hugh P),Noma(Ken-ichi),Ebina(Hirotaka),L… Nature 2008-03-05

Transposable elements and their remnants constitute a substantial fraction of eukaryotic genomes. Host genomes have evol...

CENP-O class proteins form a stable complex and are required for proper kinetoc…

Hori(Tetsuya),Okada(Masahiro),Maenaka(Katsum… Mol Biol Cell 2008-11-10

We previously identified a multisubunit complex (CENP-H/I complex) in kinetochores from human and chicken cells. We show...

Epigenetics regulate centromere formation and kinetochore function.

Gieni(Randall S),Chan(Gordon K T),Hendzel(Mi… J Cell Biochem 2008-10-15

The eukaryote centromere was initially defined cytologically as the primary constriction on vertebrate chromosomes and f...

Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human ce…

Orthaus(Sandra),Biskup(Christoph),Hoffmann(B… Chembiochem 2008-02-25

DNA segregation in mammalian cells during mitosis is an essential cellular process that is mediated by a specific subchr...

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