Chromosome segregation during mitosis requires the assembly of a large proteinaceous structure termed the kinetochore. I...
CENP-A is a centromere-specific histone H3 variant that is essential for kinetochore formation. Here, we report that the...
In both yeast and mammals, uncapped telomeres activate the DNA damage response (DDR) and undergo end-to-end fusion. Prev...
Aurora-B and -C kinases are members of the Aurora serine/threonine kinase family of mitotic regulators. Aurora-B kinase ...
Five non-allelic histone H3 variants, H3.1, H3.2, H3.3, H3t and CENP-A, have been identified in mammals. H3t is robustly...
There is an increased risk of lymphoma subsequent to autoimmune conditions. Autoimmune disorders may occur in the course...
The centromere is a chromatin region that serves as the spindle attachment point and directs accurate inheritance of euk...
The centromere is the chromosomal locus that guides faithful inheritance. Centromeres are specified epigenetically, and ...
Chromosome segregation in mitosis is orchestrated by dynamic interaction between spindle microtubules and the kinetochor...
Kinesin and dynein are the two families of microtubule-based motors that drive much of the intracellular movements in eu...
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