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Synthetic lethal interactions identify phenotypic "interologs" of the spindle a…

Tarailo(Maja),Tarailo(Sanja),Rose(Ann M) Genetics 2008-03-06

Here, we report genetic interactions with mdf-1(gk2)/MAD1 in Caenorhabditis elegans. Nine are evolutionarily conserved o...

cin-4, a gene with homology to topoisomerase II, is required for centromere res…

Stanvitch(Gerald),Moore(Landon L) Genetics 2008-03-27

The back-to-back geometry of sister kinetochores is essential in preventing loss or damage of chromosomes during mitosis...

Inactivation of a human kinetochore by specific targeting of chromatin modifier…

Nakano(Megumi),Cardinale(Stefano),Noskov(Vla… Dev Cell 2008-05-19

We have used a human artificial chromosome (HAC) to manipulate the epigenetic state of chromatin within an active kineto...

The mitotic kinesin CENP-E is a processive transport motor.

Yardimci(Hasan),van Duffelen(Marilyn),Mao(Yi… Proc Natl Acad Sci U S A 2008-05-12

In vivo studies suggest that centromeric protein E (CENP-E), a kinesin-7 family member, plays a key role in the movement...

Induction of interferon-alpha by scleroderma sera containing autoantibodies to …

Kim(Daniel),Peck(Anders),Santer(Deanna),Pato… Arthritis Rheum 2008-08-08

Peripheral blood cells (PBMCs) from some patients with systemic sclerosis (SSc) express an interferon-alpha (IFNalpha) s...

CENP-V is required for centromere organization, chromosome alignment and cytoki…

Tadeu(Ana Mafalda Baptista),Ribeiro(Susana),… EMBO J 2008-10-27

The mechanism of mitotic chromosome condensation is poorly understood, but even less is known about the mechanism of for...

The centromeric satellite of the wedge sole (Dicologoglossa cuneata, Pleuronect…

de la Herrán(R),Robles(F),Navas(J I),López-F… Cytogenet Genome Res 2008-09-17

Here, a new satellite-DNA family is isolated and characterized from wedge sole, Dicologoglossa cuneata Moreau, 1881 (Ple...

Localization of spindle checkpoint proteins in cells undergoing mitosis with un…

Johnson(Mary Kathrine),Cooksey(Amanda M),Wis… Cell Motil Cytoskeleton 2008-11-18

CHO cells can be arrested with hydoxyurea at the beginning of the DNA synthesis phase of the cell cycle. Subsequent trea...

Beta-cell proliferation, but not neogenesis, following 60% partial pancreatecto…

Ackermann Misfeldt(Amanda),Costa(Robert H),G… Diabetes 2008-12-31

This study was designed to determine whether the transcription factor FoxM1 was required for regeneration of beta-cell m...

Inhibition of protein deacetylation by trichostatin A impairs microtubule-kinet…

Ma(Y),Cai(S),Lu(Q),Lu(X),Jiang(Q),Zhou(J),Zh… Cell Mol Life Sci 2008-11-24

Inhibition of protein deacetylation arrests cells in mitosis, but the mechanism is unknown. To understand why inhibiting...

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