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Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUM…

Gao(Shijuan),Wu(Jiaoxiang),Liu(Ran-Yi),Li(Ji… J Virol 2015-03-16

...AIMP2 from ubiquitin-mediated degradation in NS2-transfected cells and AIMP2 functioned as a positive regulator of IAV r...

Protein-protein interactions and multi-component complexes of aminoacyl-tRNA sy…

Kim(Jong Hyun),Han(Jung Min),Kim(Sunghoon) Top Curr Chem 2014-08-20

...AIMP2/p38, and AIMP/p18. The distinct ARS proteins are also connected to diverse protein networks to carry out biologica...

Parkin plays a role in sporadic Parkinson's disease.

Dawson(Ted M),Dawson(Valina L) Neurodegener Dis 2014-09-23

...AIMP2 and PARIS (ZNF746).,Strategies aimed at maintaining parkin in a catalytically active state or interfering with the...

Architecture and metamorphosis.

Guo(Min),Yang(Xiang-Lei) Top Curr Chem 2014-08-20

...AIMP2/p38, and AIMP3/p18), and has a molecular weight of 1.5 million Dalton. The MSC has been proposed to have a functio...

Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine…

Imam(Syed Z),Trickler(William),Kimura(Shinya… PLoS One 2014-01-10

...AIMP2. We propose that compounds of the INNO-406 class of Abl inhibitors will be useful new neuroprotective drugs for th...

The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical …

Karuppagounder(Senthilkumar S),Brahmachari(S… Sci Rep 2014-08-19

...AIMP2 suggesting that the protective effect of nilotinib may, in part, be parkin-independent or to the pharmacodynamics ...

Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purificat…

Kim(Kyutae),Park(Seong-Jun),Na(Seungjin),Kim… PLoS One 2014-09-27

...AIMP2 and KARS as a bait protein. Mass spectrometric data were funneled into SAINT software to distinguish true interact...

Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour r…

Lee(Hee Sook),Kim(Dae Gyu),Oh(Young Sun),Kwo… Biochem J 2013-11-04

...AIMP2-DX2, an exon2-deleted splicing variant of AIMP2, is up-regulated in lung cancer and competitively suppresses the p...

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.

Lee(Yunjong),Karuppagounder(Senthilkumar S),… Nat Neurosci 2013-11-25

...AIMP2), led to a selective, age-dependent, progressive loss of dopaminergic neurons via activation of poly(ADP-ribose) p...

Rapid detection of exon 2-deleted AIMP2 mutation as a potential biomarker for l…

Jo(Seong-Min),Kim(Youngwook),Jeong(Young-Su)… Biosens Bioelectron 2013-10-21

...AIMP2 (AIMP2-DX2) mutation to a specific cancer. Here, we demonstrate the rapid and simple detection of the AIMP2-DX2 mu...

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