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The amyloid beta-protein precursor and its mammalian homologues. Evidence for a…

Bush(AI),Pettingell(WH),de Paradis(M),Tanzi(… J Biol Chem 1994-10-28

...APLP2 upon heparin-Sepharose chromatography. APP, APLP1, and APLP2 all bind zinc-chelating Sepharose, indicating that th...

Association of a novel human FE65-like protein with the cytoplasmic domain of t…

Guénette(SY),Chen(J),Jondro(PD),Tanzi(RE) Proc Natl Acad Sci U S A 1996-10-01

...APLP2 (amyloid precursor-like proteins), were also tested for interaction with hFE65L. APLP2, but not APLP1, was found t...

Facilitation of stress-induced phosphorylation of beta-amyloid precursor protei…

Taru(H),Suzuki(T) J Biol Chem 2004-05-14

...APLP2 (with respect to the numbering conversion for the APLP2 763 isoform) in their cytoplasmic domains acts as a molecu...

The crystal structure of amyloid precursor-like protein 2 E2 domain completes t…

Roisman(LC),Han(S),Chuei(MJ),Connor(AR),Capp… FASEB J 2019-00-00

...APLP2 and compared that with its paralogues APP and APLP2, demonstrating high overall structural similarities. The cryst...

Identification of the Alzheimer's disease amyloid precursor protein (APP) and i…

Needham(BE),Wlodek(ME),Ciccotosto(GD),Fam(BC… J Pathol 2008-06-00

...APLP2). Whilst a number of activities have been attributed to the APP family, an overall function has not been definitiv...

Identification and comparative analysis of differentially expressed proteins in…

Shen(Y),Yu(Y),Guo(H),Tang(Z),Yu(FS),Zhou(J) Eur J Neurosci 2002-09-00

...APLP2 and tyrosine hydroxylase in the nigral neurons. Moreover, reduction of APLP2-positive neurons in the substantia ni...

APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.

Tkatchenko(AV),Tkatchenko(TV),Guggenheim(JA)… PLoS Genet 2015-08-00

...Aplp2. This work identifies APLP2 as one of the "missing" myopia genes, demonstrating the importance of a low-frequency ...

APLP2 as a molecular link between immune regulation and bone metabolism in hepa…

Liang(Z),Zheng(J),Su(Z),Wu(B),Yang(H),Bai(S)… Cancer Cell Int 2026-06-14

...APLP2 showed increased expression specifically in cancerous tissues. Reduced APLP2 levels suppressed proliferation, inva...

PAT1 induces cell death signal and SET mislocalization into the cytoplasm by in…

Briand(S),Facchinetti(P),Clamagirand(C),Made… Neurobiol Aging 2011-06-00

...APLP2 at the cell surface. Down regulation experiments of PAT1 and of APP and APLP2 show that the increase of the levels...

Increased expression of amyloid precursor protein and amyloid precursor-like pr…

Araki(W),Wurtman(RJ) Brain Res Mol Brain Res 1998-05-00

...APLP2) during trophic factor deprivation-induced PCD of neuronally differentiated PC12 cells. Neuronal PC12 cells underw...

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