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Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier resp…

Al-Ahmadie(Hikmat),Iyer(Gopa),Hohl(Marcel),A… Cancer Discov 2016-06-02

...RAD50 that attenuated ATM signaling which in the context of CHK1 inhibition contributed, via synthetic lethality, to ext...

Cdk1-dependent regulation of the Mre11 complex couples DNA repair pathways to c…

Simoneau(Antoine),Robellet(Xavier),Ladouceur… Cell Cycle 2016-05-09

...Rad50-Xrs2 (MRX) complex, is regulated by cell cycle-dependent phosphorylation specifically in mitosis. This modificatio...

Identification and characterization of cellular proteins interacting with Hepat…

Paingankar(Mandar S),Arankalle(Vidya A) Virus Res 2016-05-25

...RAD50 and TLE-4 interacted with HEV 5'UTR. RNA immuno-precipitation studies further confirmed the interaction of DHX9, D...

Detection of novel germline mutations for breast cancer in non-BRCA1/2 families.

Aloraifi(Fatima),McDevitt(Trudi),Martiniano(… FEBS J 2016-02-25

...RAD50 (~ 3%), CHEK2 (~ 2%), TP53 (~ 1%), PALB2 (~ 1%), and MRE11A (~ 1%). However, we also identified novel pathogenic v...

The MRN complex is transcriptionally regulated by MYCN during neural cell proli…

Petroni(M),Sardina(F),Heil(C),Sahún-Roncero(… Cell Death Differ 2016-10-14

...RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replicati...

Targeting of β1 integrins impairs DNA repair for radiosensitization of head and…

Dickreuter(E),Eke(I),Krause(M),Borgmann(K),v… Oncogene 2016-08-15

...Rad50 and Nbs1. Further, we identified Ku70, Ku80 and DNA-PKcs but not poly(ADP-ribose) polymerase (PARP)-1 to reside in...

Expression of the Mre11-Rad50-Nbs1 complex in cisplatin nephrotoxicity.

Kim(Young-Jung),Kim(Tae-Won),Park(So-Ra),Kim… Environ Toxicol Pharmacol 2016-06-07

...Rad50, and Nbs1 (MRN) complex is associated with DNA repair mechanisms in cisplatin-induced acute renal failure. Rats we...

Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.

Seifert(Florian Ulrich),Lammens(Katja),Hopfn… Acta Crystallogr F Struct Bio… 2016-03-07

Together with the Rad50 ATPase, the Mre11 nuclease forms an evolutionarily conserved protein complex that plays a centra...

MST-312 Alters Telomere Dynamics, Gene Expression Profiles and Growth in Human …

Gurung(Resham Lal),Lim(Shi Ni),Low(Grace Kah… J Nutrigenet Nutrigenomics 2016-04-22

...RAD50. Co-treatment with MST-312 and the poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor PJ-34 further enhanced growth ...

The effect of immunological status, in-vitro treatment and culture time on expr…

Emam(Mehdi),Thompson-Crispi(Kathleen),Mallar… BMC Immunol 2016-01-20

...RAD50 among all tested genes were consistent after treatment of cultured BMCs with C. albicans whole yeast extract and H...

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