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Metabolic Reprogramming-Driven Lactylation: Emerging Mechanisms Linking DNA Dam…

Wang(L),Zhong(S),Zhao(J),Liu(L),Li(C) Cells 2026-06-13

...RAD51 and XLF has also been implicated in DNA repair regulation in specific experimental systems, although some mechanis...

A novel ERα-targeted hydrophobic tag degrader, overcomes tamoxifen resistance v…

Shen(R),Xin(L),Liu(J),Li(K),Deng(X),Liu(X),W… Bioorg Chem 2026-09-15

...RAD51 degradation and BRCA1/2 downregulation. The latter effect creates synthetic lethality with Olaparib. Our findings ...

TASP1-mediated cleavage of REV3L enhances the activity of DNA polymerase ζ in m…

Goulas(J),Guignier(B),Ben Yamin(B),Pouvelle(… Nat Commun 2026-06-15

...RAD51 nuclear foci and sister chromatid exchange, consistent with a compensatory shift toward homologous recombination-m...

Amphiregulin drives EGFR-dependent genome stability in colorectal cancer and re…

Park(SJ),Lee(SW),Moon(H),Jung(SM),Kim(JM),Le… Oncogene 2026-08-00

...RAD51, RPA, and γH2AX foci, resulting in a 40-60% reduction in proliferation effects that were not fully recapitulated b...

Alternative Lengthening of Telomeres is dependent on RAD52 and RAD51 gene funct…

Itriago(H),Cohn(M) G3 (Bethesda) 2026-06-16

...RAD51 gene function, while the RAD50 and RAD59 genes are not essential. This implies that the N. castellii ALT mechanism...

KPT-330-mediated XPO1 inhibition impairs homologous recombination and enhances …

Zhou(H),Liu(Q),Ren(K),Luo(Q),Yang(C),Fang(T)… Br J Cancer 2026-06-16

...RAD51/CHEK1 axis by blocking c-Myc nuclear export, reducing c-Myc abundance and promoter occupancy at the RAD51 and CHEK...

Response of MRC-5 human lung fibroblasts to FLASH and conventional radiotherapy…

Jiang(Y),Wang(X),Yang(C),Wu(J),Chen(Y),Li(J)… Comput Biol Chem 2026-10-00

...RAD51, EXO1, BIRC5, BUB1, CDC6, CDC20) were screened out via PPI network analysis, and RT-qPCR verified that their downr...

Resistance-centered pharmacology of DNA damage response-targeted therapy: Mecha…

Qin(S),An(J),Qiao(W),Zhichao(X),Siyao(T),Seo… Biomed Pharmacother 2026-08-00

...RAD51 foci assays, and AI-driven multi-omics integration to enable real-time resistance detection and mechanism-guided t...

SPOP-mediated nuclear ubiquitination degradation of p62/SQSTM1 contributes to H…

Yang(X),Zhou(Y),Huang(Q),Wang(L),Zhang(S),Ya… Oncogene 2026-08-00

...RAD51 and FLNA, RAD51 foci formation, and HR efficiency. In addition, patients-derived p62/SQSTM1 mutations in SPOP-bind...

Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and…

Katz(JN),Samentar(L),Fang(Q),Ji(JH),Li(W),Ga… Nat Commun 2026-05-20

...RAD51, the recombinase required for DNA damage repair by homologous recombination (HR) and the preservation of stressed ...

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