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The BRCA1-A complex restricts replication fork reversal-dependent DNA repair ...

Datta(A),Jackson(J),Morozov(YI),Qiu(J),Vin... bioRxiv 2026-03-22

...BRCA1-A damaged fork recognition to restrict end-resection and cause Topoisomerase I inhibitor hypersensitivity. BRCA1-A...

Re-evaluating hereditary breast and ovarian cancer risk: clinical impact of u...

Gislinge(JIP),Byrjalsen(A),Naver(KV),Claus... Fam Cancer 2026-03-27

...BRCA1/2 have been identified, highlighting the need for updated genetic evaluation in women previously classified as hig...

BARD1 recognizes pre-rRNA for DNA damage repair and rRNA biogenesis.

Huang(H),Wu(D),Yu(X) J Biol Chem 2026-05-00

...BRCA1)/BRCA1-associated RING domain 1 (BARD1) complex recognizes pre-ribosomal RNA (pre-rRNA) to coordinate the process ...

Endogenous and environmental factors that induce DNA replication defects and ...

Deshpande(M),Paniza(T),Brown(R),Heslin(K),... Sci Rep 2026-03-27

...BRCA1 carriers. Approximately 70% of BRCA1-associated breast cancers are triple negative (TNBC; progesterone (PR), HER2,...

Beyond the Surface: Deciphering the Role of Genetic Susceptibility in BIA-ALC...

Hah(YS),Lee(SJ),Hwang(J),Choi(HY) Biomedicines 2026-03-08

...BRCA1/BRCA2 and HLA associations). Methods: We conducted a narrative, evidence-based synthesis of peer-reviewed epidemio...

Gene Expression Profiles Associated with Molecular Subtypes and Pathological ...

Baulies(S),Molina-Vila(MA),Tresserra(F),Ro... Int J Mol Sci 2026-03-11

...BRCA1. Low AXL and BRCA1 expression levels were independently associated with pCR. In addition, their combined low expre...

ESCO2 Interacts with TRF1/2 and Facilitates Telomere Maintenance.

Guo(J),Ji(J),Liu(J),Tang(M) Int J Mol Sci 2026-03-13

...BRCA1, and MUS81. Moreover, we show that ESCO2 acts in epistasis with BLM in promoting telomere stability. Taken togethe...

STK11 and DNA Repair Gene Mutations Define Hereditary Subset of Middle Easter...

Bu(R),Haqawi(W),Razzaq(EAA),Azam(S),Iqbal(... Int J Mol Sci 2026-03-14

...BRCA1, BRCA2, FANCA, SLX4, RAD50, MSH6, POLD1 and NF1. Four patients (36.4%) carried PVs/LPVs in canonical FA pathway ge...

MicroRNA Mimics Based on the miR-15/107 Consensus Sequence Sensitise NSCLC Ce...

Carpenter(C),Simmons(N),Davis(WJH),Thompso... Int J Mol Sci 2026-03-16

...BRCA1, suggesting a multi-target mechanism of action. Long-term assays showed that the mimics reduced the survival and d...

Assessment of Homologous Recombination System Gene Expression in Chemological...

Tsyganov(MM),Bulatova(DZ),Fedorenko(AA),Lo... Curr Issues Mol Biol 2026-03-04

...BRCA1 and BRCA2, contributes to genomic instability and the development of more aggressive tumor clones. The use of chem...

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