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Lynch Syndrome as a Spectrum of Four Distinct Genetic Disorders: Toward Genotyp…

Liu(Y),Ye(S),Liu(Z),Chen(Z),Liang(X) Cancers (Basel) 2026-02-03

...MSH2, MSH6, and PMS2). This approach fails to leverage gene-specific characteristics for precision healthcare delivery. ...

Pediatric NTRK-rearranged gliomas: A clinicopathological and molecular analysis…

Zhao(J),Tian(F),Ding(D),Feng(J),Shi(W),Liu(J… Pathol Res Pract 2026-04-00

...MSH2, ARID4A, and CHEK1. DNA methylation profiling showed no collective methylation class and low-confidence matches to ...

Uptake of cascade tests in relatives of patients undergoing cancer precision me…

Matsubayashi(H),Kiyozumi(Y),Ishihara(E),Hara… Jpn J Clin Oncol 2026-05-07

...MSH2 [1], and RAD51C [1]. The 23 patients with GPVs had 43 relatives eligible for cascade test and 22 non-eligible relat...

NOX4-derived oxidative DNA damage impairs thyroid differentiation through an ep…

Radom(M),Buffet(C),Cazarin(J),Harinquet(M),d… Int J Biol Sci None

...MSH2/MSH6 proteins, which in cooperation with DNMT1, convert these lesions into transcription-blocking events. This mech...

Case Report: A case of Lynch syndrome-related glioblastoma with coexisting MSH2…

Huang(L),Tang(X),Cao(D),Li(Y),Zhu(X) Front Oncol None

...MSH2 splicing disruption and MSH6 frameshift mutation synergistically exacerbated genomic instability, highlighting a po...

Global Proteomic Analysis of Colorectal Cancers Stratified by Microsatellite In…

Tobias(F),Sekera(ER),Xiong(X),Fang(F),Hampel… bioRxiv 2026-01-29

...MSH2 (EPCAM), MSH6, and PMS2. While the genetic changes associated with Lynch Syndrome have previously been characterize...

Primary peritoneal clear cell carcinoma with metastasis mimicking ovarian carci…

Kim(NI),Lee(JS),Lee(KH),Kim(SS) J Ovarian Res 2026-02-07

...MSH2 and MSH6. Next-generation sequencing revealed ARID1A loss and somatic PIK3CA mutations. No primary ovarian, endomet...

Variant reclassification in cancer susceptibility genes and an updated variant …

Can(ND),Akcay(IM),Celik(E),Ciftci(C),Unal(B)… Hum Genomics 2026-02-08

...MSH2, and CHEK2. Notably, CHEK2 was among the most frequently mutated genes, and harbored the highest number of distinct...

Tiny plastic, big trouble: how polystyrene nanoparticles impact DNA-damage repa…

Berezowitz(JD),Fish(MC),Mehanna(LE),Knicely(… Soft Matter 2026-02-18

...MSH2. High concentrations of polystyrene were required for observable decreases in cell viability, particularly in ester...

Artificial intelligence application in routine pathology: ChatGPT-4.0 and Gemin…

Salzano(S),Broggi(G),Zanelli(M),Zizzo(M),Fab… Surg Oncol 2026-04-00

...MSH2/MSH6 loss (60%) compared to MLH1/PMS2 loss (70%). This drop in sensitivity was attributed to the models' reluctance...

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