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An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kin…

Hegnauer(Anna Maria),Hustedt(Nicole),Shimada… EMBO J 2012-12-03

...Slx4, Slx5 or Slx8.

RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere …

Vannier(Jean-Baptiste),Pavicic-Kaltenbrunner… Cell 2012-07-02

...SLX4 nuclease complex, resulting in loss of the telomere as a circle. Depleting SLX4 or blocking DNA replication abolish...

Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families.

Fernández-Rodríguez(Juana),Quiles(Francisco)… BMC Cancer 2012-06-25

...SLX4 gene, which encodes for a scaffold protein involved in the repair of interstrand cross-links, have recently been id...

Delineation of joint molecule resolution pathways in meiosis identifies a cross…

Zakharyevich(Kseniya),Tang(Shangming),Ma(Yun… Cell 2012-06-08

...Slx4(BTBD12), and Yen1(GEN1). Using physical monitoring of recombination during budding yeast meiosis, we show that all ...

BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination inte…

De Muyt(Arnaud),Jessop(Lea),Kolar(Elizabeth)… Mol Cell 2012-06-11

...Slx4, nucleases with minor roles in wild-type meiosis. We conclude that Sgs1 is a primary regulator of recombination pat...

Sequencing analysis of SLX4/FANCP gene in Italian familial breast cancer cases.

Catucci(Irene),Colombo(Mara),Verderio(Paolo)… PLoS One 2012-08-27

...SLX4 may not exceed 0.6%. Our results indicate that testing for SLX4 germline mutations is unlikely to be relevant for t...

SLX-1 is required for maintaining genomic integrity and promoting meiotic noncr…

Saito(Takamune T),Mohideen(Firaz),Meyer(Kath… PLoS Genet 2012-11-05

...SLX4 complex, which includes structure-specific nucleases such as XPF, MUS81, and SLX1, plays important roles in the rep...

Components of a Fanconi-like pathway control Pso2-independent DNA interstrand c…

Ward(Thomas A),Dudášová(Zuzana),Sarkar(Sovan… PLoS Genet 2012-12-17

...Slx4, respectively, are also components of the genetic pathway controlled by Mph1-Mgm101-MutSα. Together this suggests t...

Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.

Sengerová(Blanka),Wang(Anderson T),McHugh(Pe… Cell Cycle 2012-08-29

...SLX4, to initiate ICL repair, with the MUS81-EME1 fork incision activity becoming important in the absence of the XPF-SN...

Three structure-selective endonucleases are essential in the absence of BLM hel…

Andersen(Sabrina L),Kuo(H Kenny),Savukoski(D… PLoS Genet 2012-02-10

...SLX4-SLX1. The Bloom syndrome helicase, BLM, plays key roles in preventing mitotic crossover, either by blocking the for...

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