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TP53 BRCA1 CRISPR single-cell cancer

Ma(H),Xu(Z),Chung(W),Weng(C),Peng(Y) medRxiv 2025-07-03

...BRCA1 and BRCA2 genes. By analyzing 162 unique cited publications supporting VUS reclassifications, we examined the accu...

Liu(J),Zhang(E),Su(S),Xie(S),Liu(R),Ren(L)... Toxicology 2025-11-00

...BRCA1, treatment significantly alleviate SiNPs-stimulated down-regulation on expressions of BRCA1 and GPX4. Our findings...

Ul Haq(S),Aamir(A),Mighton(C),Hueniken(K),... HGG Adv 2025-07-10

...BRCA1 (1%; 95% CI: 1%-3%), BRCA2 (1%; 95% CI: 1%-3%), and TP53 (1%; 95% CI: 0%-3%). Patients with P/LP variants in DNA d...

Garje(R),Riaz(IB),Naqvi(SAA),Rumble(RB),Ta... J Clin Oncol 2025-07-10

...BRCA1/2 alterations who did not receive prior ARPI, the combination of PARPi and ARPI (talazoparib + enzalutamide, olapa...

Khoury(R),Longobardi(G),Barnatan(TT),Venke... J Control Release 2025-07-10

Poly (ADP-ribose) polymerase inhibitors (PARPi) have revolutionized the treatment landscape for patients suffering from ...

Chang(X),Zhang(Y),Wang(Q),Yang(W),Zhang(R)... Cell Signal 2025-11-00

...BRCA1/2 mutations. In our previous study, we found that CX-5461 inhibited GSH synthesis and promote lipid peroxidation i...

Ji(X),Redelings(B),Su(S),Bao(H),Deng(WM),H... ArXiv 2025-07-11

...BRCA1 gene in primates and mutational dynamics in viral sequences from the recent mpox epidemic. Our novel algorithm enh...

Wieleba(I),Smoleń(P),Czukiewska(E),Szcześn... Int J Mol Sci 2025-07-12

...BRCA1 and BRCA2 genes. Additional genes with a significant influence on cancer risk were selected for genetic panel scre...

Wang(J),Zheng(Q),Chen(J) Front Pharmacol 2025-00-00

...BRCA1 and PALB2, who achieved PR lasting approximately 7 months following salvage treatment with olaparib. We considered...

Cortés-Salgado(A),Serrano(JJ),Cordero Pere... Oncologist 2025-08-04

...BRCA1/2 mutation carriers (gBRCA1/2m) vs non-carriers (gBRCA1/2wt). Secondary objectives included differences in MDBB an...

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