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Novel Therapies in Advanced Pancreatic Cancer: A Peak Beyond the Realms of Ge...

Dave(P),Beriwala(V),Parikh(C),Uddin(A),Day... Cureus 2025-07-00

...BRCA1/2, PALB2, and NRG1 fusions) that offer potential targets for precision therapy. Bispecific antibodies, such as ant...

Long-Term Adverse Events Following Early Breast Cancer Treatment with a Focus...

Obispo(B),Bailleux(C),Cantos(B),Zamora(P),... Cancers (Basel) 2025-07-30

...BRCA1/BRCA2), (gBRCAm), who are typically young women, often require more aggressive therapeutic interventions. These mu...

Discovery of a novel non-toxic analog of clofarabine for the treatment of tri...

Moukha-Chafiq(O),Boohaker(R),Bratton(LD),Y... Bioorg Med Chem Lett 2025-12-01

...BRCA1/2 mutations. Despite initial response, clinical resistance rapidly develops, and few options exist as later-line t...

Indian medicinal phytocompounds for targeting apoptosis and high-penetrance g...

Kumari(R),Banerjee(S) BMC Mol Cell Biol 2025-07-30

...BRCA1, BRCA2, and BAX, along with other apoptotic genes involved in tumorigenesis, apoptosis, and drug resistance. Targe...

Retrotransposon methylation profiles and survival in Black women with high-gr...

Colin-Leitzinger(C),Lawson-Michod(KA),John... Clin Epigenetics 2025-07-30

...BRCA1/BRCA2 mutations. Two RE methylation clusters were identified. Cluster 1 exhibited a more hypomethylated RE profile...

Exploring the utility of ctDNA testing in high-risk breast cancer patients in...

Wong(K),Kameoka(A),Fukui(JA) Ther Adv Med Oncol 2025-00-00

...BRCA1/BRCA2 mutations), <40 years old at diagnosis, or history of breast cancer recurrence-were offered tumor-informed c...

Hidden SVA retrotransposon insertion in BRCA1 revealed by nanopore targeted s...

Ohori(S),Waraya(M),Fujisaki(K),Sangai(T),A... J Hum Genet 2025-10-00

...BRCA1 of a proband and her mother, both of whom had inconclusive conventional BRCA1/2 genetic test results, by targeted ...

IL-6R expression is an independent prognostic factor in high-grade serous ova...

Maagdenberg(AM),Vledder(A),Paijens(ST),Pla... BJC Rep 2025-07-08

...BRCA1/BRCA2 mutation, primary treatment, and surgical outcome are strong independent prognostic factors of overall survi...

Porphyrin based hydrogen bond organic frameworks as enhanced ECL luminophore ...

Pan(JJ),Chen(M),Zhu(HT),Wang(AJ),Yuan(PX),... Anal Chim Acta 2025-10-15

...BRCA1) by signal recovery after removing a black hole quencher (BHQ) linked DNA, showing a wide linear range from 1.0 pM...

Epigenetic Drivers of Chemoresistance in Nucleobase and Nucleoside Analog The...

Kaszycki(J),Kim(M) Biology (Basel) 2025-07-09

...BRCA1/2), and autophagy-related genes (e.g., CSNK2A1, BNIP3). Furthermore, emerging roles for long non-coding RNAs (lncR...

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