...BRCA1/2 mutation. This study showed the antitumor activity of AA in PC cells and PDCs, indicating that KRAS G12D identif...
...BRCA1, a duplication of exons 18-19 and a triplication of exons 1-2 in two independent families. Utilizing Optical Genom...
...BRCA1 or BRCA2 inactivation, leads to homologous recombination deficiency (HRD), forcing cells to rely on error-prone me...
...BRCA1/2 pathogenic variants who were treated at our institution. A retrospective chart review was performed. The clinica...
...BRCA1 and BRCA2, but a positive correlation with ESR1 in the basal subtype. CYP4F12 has a significant positive correlati...
...BRCA1 and BRCA2, stabilizing RAD51 filaments. Mutations in these genes compromise HR, increasing susceptibility to vario...
...BRCA1/BRCA2/PALB2 pathogenic variants. The precise BC risk threshold for offering risk-reducing mastectomy (RRM) for BC ...
...Brca1-/- and KPCA.B syngeneic mouse models of ovarian cancer, we defined the contribution of TG2 in the TME to the metas...
...BRCA1-interacting helicase 1 (BRIP1), and interacted with these proteins to prevent cell death in response to DNA damage...
...BRCA1-deficient OC via synthetic lethality strategy. Representative compound 4 displayed the most potent antitumor effec...
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