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TP53 BRCA1 CRISPR single-cell cancer

Beutel(AK),Halbrook(CJ),Ekizce(M),Lindenma... United European Gastroenter... 2025-09-00

...BRCA1/2 mutation carriers have an approved treatment option with the PARP inhibitor (PARPi) olaparib. Characterizing HR-...

Zhu(X),Fu(Z),Aceto(G),St-Germain(J),Liu(K)... Cancer Res 2025-08-15

...BRCA1 expression. Elevated R-loop in SCCOHT sequestered BRCA1, limiting its availability for DNA damage repair. Proximit...

Throner(S),Feng(T),Andersen(JN),Bandi(M),E... Bioorg Med Chem Lett 2025-08-15

USP1 (ubiquitin-specific peptidase 1) is a deubiquitinating enzyme that has been identified as essential in BRCA1/2 muta...

Andour(L),Hagenaars(SC),Vangangelt(K),Aalb... Int J Cancer 2025-08-15

...BRCA1 (n = 47, 47%) and BRCA2 (n = 29, 29%) carriers. Invasive cancer was diagnosed in 100 cases: 76% (n = 76) had a PV ...

Zhao(B),Tang(X) Front Genet 2025-00-00

...BRCA1, GSN, KRT17, SCD, and SNCG). Kaplan-Meier curves for the TCGA training cohort (P < 0.0001), testing cohort (P = 0....

Elmetnawy(W),Nader(H),ElNahas(T),Sabet(S),... Sci Rep 2025-07-18

...BRCA1/2 PVs/LPVs were 58 patients (11.6%) of whom 34 (6.8%) had BRCA1 PVs/LPVs and 24 (4.8%) had BRCA2 PVs/LPVs. Patient...

Li(H),Wu(H),Li(S),Wang(Q),Li(G),Ma(X),Gong... iScience 2025-07-18

...BRCA1/2 mutations. Nevertheless, resistance to PARP inhibitors often develops. Thus, it is imperative to identify strate...

Huang(ZC),Feng(YL),Liu(Q),Chen(RD),Liu(SC)... Nucleic Acids Res 2025-07-19

...Brca1-deficient cells. Disrupting RAD51 loading reduced TDs in wild-type cells but not in Brca1-deficient cells, indicat...

Kerivan(L),Wagner(J),Nye(L),Balanoff(C),Je... Ann Surg Oncol 2025-10-00

...BRCA1/2, PALB2, PTEN, STK11, TP53) or moderate (ATM, BARD1, CHEK2, RAD51C/D) penetrance gene mutation. Multivariable log...

Kumari(R),Banerjee(S) BMC Mol Cell Biol 2025-07-30

...BRCA1, BRCA2, and BAX, along with other apoptotic genes involved in tumorigenesis, apoptosis, and drug resistance. Targe...

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