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TP53 BRCA1 CRISPR single-cell cancer

Zhu(X),Fu(Z),Aceto(G),St-Germain(J),Liu(K)... Cancer Res 2025-08-15

...BRCA1 expression. Elevated R-loop in SCCOHT sequestered BRCA1, limiting its availability for DNA damage repair. Proximit...

Throner(S),Feng(T),Andersen(JN),Bandi(M),E... Bioorg Med Chem Lett 2025-08-15

USP1 (ubiquitin-specific peptidase 1) is a deubiquitinating enzyme that has been identified as essential in BRCA1/2 muta...

Andour(L),Hagenaars(SC),Vangangelt(K),Aalb... Int J Cancer 2025-08-15

...BRCA1 (n = 47, 47%) and BRCA2 (n = 29, 29%) carriers. Invasive cancer was diagnosed in 100 cases: 76% (n = 76) had a PV ...

Dagdeviren(ZC),Amac(O),Dere(Y),Derekoylu(E... Cureus 2025-08-00

...BRCA1-associated protein-1 (BAP1). Following the diagnosis of primary tunica vaginalis mesothelioma, the patient underwe...

Shou(Y),Liu(R),Xiong(H),Chen(X),Huang(L),H... J Transl Med 2025-08-19

...BRCA1/RAD51-mediated repair programs. Furthermore, lactylation-dependent miRNA signals disseminate via extracellular ves...

Sierocki(W),Kornowska(L),Slapal(O),Koska(A... Diagnostics (Basel) 2025-08-22

...BRCA1/2 testing was common, but Oncotype DX was not. For 314 HR+ HER2- patients, stage IA (44%) was most common, with no...

Yao(M),Liu(C),Ping(H),Meng(K),Li(X),Li(Q),... Mol Med Rep 2025-11-00

...BRCA1, FANCT/UBE2T, FANCU/XRCC2, FANCV/REV7, FANCW/RFWD3), endometrial cancer (type I: Endometrioid adenocarcinoma; Type...

Kramer(CJH),van Wijk(LM),Ruano(D),Gelpke-V... Br J Cancer 2025-11-00

...BRCA1/BRCA2/PALB2 pathogenic variants in the prospective cohort. Moreover, the success rate of the low-resolution testin...

Zuo(Y),Liu(X),Pang(Y),Chen(X),Li(X),Gao(J)... Front Oncol 2025-00-00

...BRCA1/2 alterations, and a molecular profile consistent with microsatellite stability and low tumor mutational burden. W...

Hasegawa(Y),Miura(S),Nagata(K),Komatsu(N),... Cureus 2025-08-00

...BRCA1/2 pathogenic variant, or (2) had a family history and were confirmed as carriers. BRCA1/2 testing was performed us...

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