...BRCA1. Additionally, the L-Arg and 5-FU combination downregulates PI3K/AKT signaling. AZD-7648 (a DNA-PKcs inhibitor) an...
...BRCA1 in hereditary breast cancer. BRCA1 ensures genomic stability through its roles in DNA repair, cell cycle checkpoin...
Mutations in the BRCA1 and BRCA2 genes significantly increase the risk of hereditary cancers, mainly of the breast and o...
...BRCA1</i> (p = 0.0379), and <i>KMT2A</i> (p = 2.06×10<sup>-5</sup>) were associated with a...
...BRCA1/2 and TP53 among the most frequently mutated genes. While somatic mutations such as KRAS and EGFR were commonly re...
...BRCA1 and BRCA2 are well-established high-risk contributors, the broader landscape of germline pathogenicity across brea...
...BRCA1 and BRCA2 in underrepresented populations. To determine P/LP variants in BRCA1 and BRCA2 in women with breast canc...
...BRCA1/BRCA2 pathogenic variants. Participants could choose RRES, RRSO, or no surgery at entry. Sample size requirements ...
...BRCA1/2 testing for hereditary breast and ovarian cancer diagnosis. The 72 respondents included patients with BRCA1/2 pa...
...BRCA1/2 and ATM. Elimusertib prolonged EFS-2 in three of five models with known PARP inhibitor resistance. Pharmacodynam...
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