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gDNA enrichment by a transposase-based technology for NGS analysis of the who...

Chevrier(Sandy),Boidot(Romain) J Vis Exp 2015-08-11

...BARD1, BRCA1, BRCA2, BRIP1, CHEK2, PALB2, RAD50, RAD51C, RAD80, and TP53) from promoter to 3'-UTR in 24 patients simulta...

The BRCA1 variant p.Ser36Tyr abrogates BRCA1 protein function and potentially...

Christou(Charita M),Hadjisavvas(Andreas),K... PLoS One 2015-01-20

...BARD1. Further, co-precipitation analysis of nuclear and cytosolic extracts as well as immunofluorescence studies showed...

BRCA1 is a histone-H2A-specific ubiquitin ligase.

Kalb(Reinhard),Mallery(Donna L),Larkin(Con... Cell Rep 2015-05-26

...BARD1 ubiquitin ligase remain unclear. Here, we show that BRCA1/BARD1 specifically ubiquitylates histone H2A in its C-te...

Whole-exome sequencing identifies rare pathogenic variants in new predisposit...

Esteban-Jurado(Clara),Vila-Casadesús(Maria... Genet Med 2015-09-18

...BARD1.,We identified new potential colorectal cancer predisposition variants in genes that have a role in cancer predisp...

KSR1 regulates BRCA1 degradation and inhibits breast cancer growth.

Stebbing(J),Zhang(H),Xu(Y),Lit(L C),Green(... Oncogene 2015-07-27

...BARD1) and checkpoint kinase 1 (Chk1) levels. Phospho-profiling of major components of the canonical Ras-RAF-mitogen-act...

Long non-coding RNA and microRNAs might act in regulating the expression of B...

Pilyugin(Maxim),Irminger-Finger(Irmgard) Int J Biochem Cell Biol 2015-05-21

...BARD1 and cancer-associated BARD1 mRNAs, and that BARD1 9'L counteracts the effect of miR-203 and miR-101, As BARD1 9'L ...

Inherited predisposition to breast cancer among African American women.

Churpek(Jane E),Walsh(Tom),Zheng(Yonglan),... Breast Cancer Res Treat 2015-09-28

...BARD1, ATM, PTEN, or TP53. The mutational allelic spectrum was highly heterogeneous, with 57 different mutations in 65 p...

Inherited mutations in 17 breast cancer susceptibility genes among a large tr...

Couch(Fergus J),Hart(Steven N),Sharma(Priy... J Clin Oncol 2015-04-20

...BARD1, RAD51D, RAD51C, and BRIP1 (0.3% to 0.5%). Patients with TNBC with mutations were diagnosed at an earlier age (P <...

Deubiquitination of γ-tubulin by BAP1 prevents chromosome instability in brea...

Zarrizi(Reihaneh),Menard(Julien Albert),Be... Cancer Res 2015-07-08

...BARD1-dependent ubiquitination of γ-tubulin causes centrosome amplification. In the current study, we identified BRCA1-a...

Characterization of LGALS3 (galectin-3) as a player in DNA damage response.

Carvalho(Renato S),Fernandes(Vanessa C),Ne... Cancer Biol Ther 2015-02-13

...BARD1, the main partner of breast and ovarian cancer susceptibility gene product BRCA1, both involved in HR pathway. In ...

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