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TP53 BRCA1 CRISPR single-cell cancer

Lazarides(K),Engel(JL),Meseonznik(M),Feng(... Mol Cancer Ther 2025-09-02

...BRCA1/2-mutated cancers and found that POLB knockout (KO) along with PARPi treatment enhanced loss of viability in BRCA1...

Canson(DM),Parsons(MT),Moir-Meyer(G),Dumen... Genome Res 2025-09-02

BRCA1 and BRCA2 germline variant classification is vital for clinical management of families with hereditary breast and ...

Vlaming(M),Koole(W),van Moorselaar(RJA),Bl... BJU Int 2025-12-00

...BRCA1, BRCA2, ATM, CHEK2 and PALB2 was offered to patients with mPCa. We assessed the prevalence of gPVs and compared it...

Mahiou(K),Bonneau(C),Coutant(C),Martin(AL)... Clin Breast Cancer 2025-12-00

Breast cancer affects over 61,000 women annually in France. While only 5-10% of breast cancers are hereditary, BRCA1/2 m...

Yamane(N),Matoba(Y),Yamazaki(T),Uyama(T),E... Case Rep Oncol 2025-00-00

...BRCA1 mutation. This finding suggests that BRCA1-associated USC may be sensitive to poly ADP-ribose polymerase inhibitor...

Johnson(M),Turcotte(S) Front Cell Dev Biol None

...BRCA1-associated protein-1 (BAP1), have been recognized as common in ccRCC. Although these genomic alterations are centr...

Abdurahman(A),Abulizi(A),Abudukeremu(A),Zh... Front Vet Sci None

...BRCA1 binding sites (BBS) were identified within this promoter region. Subsequent experimental results suggest that BRCA...

Kong(M),Jia(J),Liu(C),Liu(H),Zhang(S) Front Med (Lausanne) None

...BRCA1, TOP2A, BRCA2, BUB1B, HSP90AA1, PLK4, and EDIL3), with EDIL3 showing the greatest increase in BA. EDIL3 is located...

Torres(W),Vargas(E),Ballen(DF),Tapiero-Rod... Front Oncol None

...BRCA1-associated SGTs. We report a Colombian family segregating the BRCA1 c.3331_3334delCAAG (p.Gln1111Asnfs*5) founder ...

Abdel-Razeq(H),Tamimi(F),Abdel-Razeq(S),Sh... Oncol Rev None

...BRCA1 and BRCA2, represents a critical tool for precision oncology, enabling individualized risk stratification and the ...

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