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TP53 BRCA1 CRISPR single-cell cancer

Ciniselli(CM),Conca(E),Bartoletti(M),Colom... JCO Precis Oncol 2025-09-00

...BRCA1 (11.7%) and BRCA2 (6.5%) variants, CGP revealed further potentially actionable alterations (amplifications and/or ...

Pavanello(M),Vieira(CM),Arenhardt(MP),Nogu... Curr Issues Mol Biol 2025-09-01

...BRCA1/2 reversion mutations, demethylation of BRCA1 and RAD51C). We also discuss controversial topics regarding HRP tumo...

Boilève(A),Brugel(M),Rémond(M),Valéry(M),D... ESMO Gastrointest Oncol 2025-09-00

...BRCA1/2, CDKN2A, and mismatch repair gene mutations, contribute to familial clustering, while other nonhereditary risk f...

Kitamura(S),Taguchi(A),Tamai(K),Yamamoto(Y... Cancer Sci 2025-11-00

...BRCA1 promoter methylation in homologous recombination-deficient ovarian cancers or MLH1 promoter methylation in deficie...

Frontera(NM),Ahsan(MD),Chandler(IR),Levi(S... Gynecol Oncol 2025-10-00

...BRCA1/2 PGV was 2.8 (95 % CI 1.5-5.4), with similar ORs for BRCA1 (3.2 [95 % CI 1.6-6.3]) and BRCA2 (2.8 [95 % CI 1.2-6....

Deenonpoe(R),Guscott(MA),Watcharadetwittay... J Pathol 2025-11-00

...BRCA1. This study provides increased understanding of the rate and potential mechanisms of CIN in CCA that may inform ne...

Pasupulati(SL),Srinivasa Rao(K),Sharma(S),... Cancer Chemother Pharmacol 2025-09-16

...BRCA1/2 breast malignancies and for local castration-resistant prostate cancer (when combined with enzalutamide) due to ...

Tani(M),Hatano(K),Ishizuya(Y),Oka(T),Kanak... Cancer Sci 2025-12-00

...BRCA1/2 mutations, due to resistance. Thus, identifying novel synthetic lethal interactions with PARP may expand treatme...

Zekavat(L),Jain(A) Int J Mol Sci 2025-09-17

...BRCA1-Associated RING Domain 1) plays a complex role in tumor biology, functioning either as a tumor suppressor or as an...

Lowran(K),Campbell(L),Cismas(E),Wu(CG) Biochemistry 2025-09-16

BRCA1 is a crucial component of homologous recombination (HR), a high-fidelity pathway for repairing double-stranded DNA...

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