...BRCA1/2 genes. The BRCA1/2 pathogenetic variants are currently used, in clinical setting, as predictive markers for PARP...
...BRCA1/2 variations, but many cases lack putative driver mutations. In this study, we performed whole-exome, whole-genome...
...BRCA1 (n = 1 each). Secondary genes altered in >5% of NCs included LDL receptor-related protein 1B (LRP1B; 10.4%), histo...
...BRCA1, along with tumor suppressor genes. Nonetheless, it has led to the non-coding portions of the genome garnering rel...
...BRCA1, TP53), and relative criteria, which contextualize functional behaviors such as metastatic potential, drug sensiti...
...BRCA1 gene being a frequent cause of breast or ovarian cancer. This study investigates hotspot mutations in exon 11 of t...
...BRCA1 and BRCA2, confers a strikingly increased lifetime risk of OC. These tumor suppressor genes encode proteins essent...
...BRCA1, 25.8 % BRCA2, and 11.3 % other high-risk mutations (RAD51C, PALB2). No tubal lesions were found in 121 cases (91....
...BRCA1. Given the repetitive nature of our genome, these findings highlight the risk of L1 insertion intermediates becomi...
...BRCA1, BRCA2, PALB2, TP53 and PTEN, with germline pathogenic or likely pathogenic variants (PVs/LPVs), substantially inc...
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