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TP53 BRCA1 CRISPR single-cell cancer

Yuan(H),Wang(T),Yao(H),Wu(L),Li(N) J Ovarian Res 2025-09-26

...BRCA1/2 gene mutations. The median duration of PARPi1 and PARPi2 in the entire cohort was 11.2 months (range: 2.0-30.4 m...

Wang(W),Yang(C),Zhao(J),Cheng(X),Chen(T),Y... Arch Biochem Biophys 2025-12-00

...BRCA1, KRAS, MSH6, SMARCA4, SRC, and TSC1) exhibited significant correlations with immune infiltration (CD8+ T cells, Tr...

Nakamura(K),Masuda(K),Seki(T),Kitago(M),Ko... Keio J Med 2025-09-25

Hereditary breast and ovarian cancer syndrome (HBOC) is traditionally associated with mutations in the BRCA1 and BRCA2 g...

Masuda(K),Kobayashi(Y),Seki(T),Yoshihama(T... Keio J Med 2025-09-25

...BRCA1/2 pathogenic variants (PVs). The cumulative risks of ovarian cancer by the age of 70 years are 40% and 18% for car...

Seki(T),Kobayashi(Y),Masuda(K),Nakamura(K)... Keio J Med 2025-09-25

...BRCA1 mutations are linked to triple-negative breast cancer, whereas BRCA2 mutations typically result in luminal-type di...

Abe(K),Kitago(M),Kobayashi(Y),Masuda(K),Se... Keio J Med 2025-09-25

...BRCA1/2. In April 2021, our hospital established the HBOC Center, which is operated by nine departments, including obste...

Özer(L),Aktuna(S),Ünsal(E) Eur J Breast Health 2025-09-25

...BRCA1/BRCA2 sequencing data and reclassified the BRCA1/2 variants of unknown significance (VUS) in Turkish patients with...

Mochirian(P),Papp(R),Mathieu(MC),Ferraro(G... J Med Chem 2025-09-25

...BRCA1 or BRCA2 mutations. Here, we describe the discovery and preclinical development of RP-2119, a selective, potent, a...

Butz(H),Patócs(A) Magy Onkol 2025-09-24

...BRCA1/2 variants, along with related screening, prevention, and management recommendations, including risk-reducing surg...

Lopez(BS) Oncogene 2025-11-00

...BRCA1 or BRCA2) in cancer result in the absence of RAD51 on damaged DNA, leaving access to alternative exclusively mutag...

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