BRCA1, a well-known tumor suppressor, maintains genomic integrity by facilitating homologous recombination (HR) repair a...
...BRCA1 is often mutated in breast and ovarian cancer, but BRCA1 mutations are also associated with PCa, although they are...
...BRCA1/2, HPC1, AR variants), premalignant lesions [proliferative inflammatory atrophy (PIA), prostatic intraepithelial n...
...BRCA1, BRCA2, and PALB2 resulted in a risk distribution that was essentially disjoint from the non-carriers, regardless ...
...BRCA1 were reported in approximately 1 and 2% of male cases, respectively. Additional germline alterations were identifi...
...BRCA1/2 gene mutations. The median duration of PARPi1 and PARPi2 in the entire cohort was 11.2 months (range: 2.0-30.4 m...
...BRCA1 predominates. The most frequent pathogenic mutation was c.4829_4830del in BRCA2, present in 8.57% of positive case...
...BRCA1, CHEK2, PALB2, ATM and MAP3K1 were associated with a risk of breast cancer, while BARD1 and ATRIP met exome-wide s...
...BRCA1, HOXB13, CDK12, MLH1, MSH2, and BRIP1 remain unimpacted. Through pathogenic ranking based on variant frequency and...
...BRCA1/BRCA2 mutation (BRCAm) status, homologous recombination deficiency (HRD) status, and tumor mutational burden (TMB)...
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