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TP53 BRCA1 CRISPR single-cell cancer

Garsed(D),Zwimpfer(T),Fereday(S),Pandey(A)... Res Sq 2025-10-03

...BRCA1-deficient HGSC with a more elevated HRD score survived significantly longer. Patients with BRCA2-deficient HGSC an...

Buckley(KH),Dungan(ME),Dinh(K),Kelly(GM),H... bioRxiv 2025-10-03

...BRCA1 or BRCA2 have increased gastric cancer (GC) risk. BRCA1 and BRCA2 are tumor suppressor genes involved in promoting...

Spirina(LV),Tsyganov(MM),Chizhevskaya(SY),... Int J Mol Sci 2025-10-06

...BRCA1, BRCA2, and FANCA genes, typically associated with thyroid tumors, were identified in the tissue of papillary thyr...

Perelmuter(S),Keenahan(L),Mecklai(A),Andre... Gynecol Oncol Rep 2025-12-00

...BRCA1/2 pathogenic variants and other hereditary ovarian cancer syndromes. While the oncologic benefits are clear, the a...

Erices(JI),González(E),Salgado(M),Barahona... Front Oncol 2025-00-00

...BRCA1/2, EGFR, ERBB2, and other genes. Exploratory analysis suggested an association between higher Mapuche ancestry and...

Dar(MAF),Nasir(N),Mujtaba(G),Afzal(M) Cureus 2025-10-00

...BRCA1-associated protein 1 (BAP1) loss on immunohistochemistry. Given advanced disease and poor performance status, the ...

Maillard(J),Roumeliotis(TI),Paranjape(E),P... J Proteome Res 2025-10-03

...BRCA1─with different status of BRCA genes grown in 2D and 3D. Using isobaric labeling proteomics, we quantified 6404 pro...

Christopher(J),Edgerley(K),McIldowie(B),Je... J Med Genet 2025-10-01

...BRCA1, BRCA2, PALB2, ATM, CHEK2, BARD1, BRIP1, RAD51C, RAD51D and mismatch repair (MMR) genes (MLH1, MSH2, MSH6 and PMS2...

Salemi(A),Zenjanab(MK),Adili Aghdam(MA),Sa... Cancer Cell Int 2025-10-03

...BRCA1, CCND1, CDK4, CDK6, CDKN1A, Rb1, and Tp53) as breast cancer key players in the MTX and SiL interaction network wit...

Beekman(MJ),Terra(L),Stuursma(A),Heemskerk... Osteoporos Int 2025-11-00

...BRCA1/2 germline pathogenic variant carriers are recommended to undergo premenopausal risk-reducing salpingo-oophorectom...

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