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TP53 BRCA1 CRISPR single-cell cancer

Li(Dapei),Dong(Qincai),Tao(Qingping),Gu(Ji... Cell Rep 2016-01-28

...BRCA1 specifically functions as an E3 ubiquitin ligase of PSMA7 ubiquitination. c-Abl/Arg regulates cellular proteasome ...

De Felice(Francesca),Marchetti(Claudia),Mu... Ann Surg Oncol 2016-05-12

Women with BRCA1 and BRCA2 mutations have substantially elevated risk of developing breast cancer. The aim of this study...

Massink(Maarten P G),Kooi(Irsan E),van Mil... Mol Oncol 2016-01-05

...BRCA1-mutated breast carcinomas could lead to a better understanding of BRCA1-associated oncogenic events and could prov...

Bayraktar(Soley),Jackson(Michelle),Gutierr... Breast J 2016-05-03

...BRCA1 (exons 2, 11, and 20) and BRCA2 (exons 10, 11, and 25) genes were chosen. Prevalence of BRCA1 exon 2 mutations wer...

Laitman(Yael),Keinan Boker(Lital),Liphsitz... Breast Cancer Res Treat 2016-01-01

...BRCA1 and BRCA2 mutation carriers are still unsettled. Cancer risks in men who were found to harbor a BRCA1 (n = 150) or...

Zhang(Wenwen),Luo(Jiayan),Chen(Fengxia),Ya... Oncotarget 2016-05-02

...BRCA1 and/or PIG3 and overall survival (OS). Moreover, we reveal that overexpression of BRCA1 significantly increased ex...

Shiovitz(S),Korde(L A) Ann Oncol 2016-04-05

...BRCA1, BRCA2, PTEN, TP53, CDH1, and STK11), which confer up to an 80% lifetime risk of breast cancer. An additional 2%-3...

van Driel(Catheleine M G),de Bock(Geertrui... Maturitas 2016-04-14

Ovarian cancer screening (OCS) for BRCA1/2 mutation carriers was stopped in our family cancer clinic in 2009 because of ...

Gau(David M),Lesnock(Jamie L),Hood(Brian L... Cell Cycle 2016-04-19

...BRCA1) has been implicated in genomic instability and cancer progression. There is emerging evidence that BRCA1 gene pro...

D'Argenio(Valeria),Esposito(Maria Valeria)... Clin Chim Acta 2016-02-22

Accurate and sensitive detection of BRCA1/2 germ-line mutations is crucial for the clinical management of women affected...

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